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Tbio
LMOD3
Leiomodin-3

Protein Summary
Description
Essential for the organization of sarcomeric actin thin filaments in skeletal muscle (PubMed:25250574). Increases the rate of actin polymerization (PubMed:25250574). The protein encoded by this gene is a member of the leiomodin family of proteins. This protein contains three actin-binding domains, a tropomyosin domain, a leucine-rich repeat domain, and a Wiskott-Aldrich syndrome protein homology 2 domain (WH2). Localization of this protein to the pointed ends of thin filaments has been observed, and there is evidence that this protein acts as a catalyst of actin nucleation, and is important to the organization of sarcomeric thin filaments in skeletal muscles. Mutations in this gene have been associated as one cause of Nemaline myopathy, as other genes have also been linked to this disorder. Nemaline myopathy is a disorder characterized by nonprogressive generalized muscle weakness and protein inclusions (nemaline bodies) in skeletal myofibers. Patients with mutations in this gene often ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420581
  • ENSP00000414670
  • ENSG00000163380
  • ENST00000475434
  • ENSP00000418645
  • ENST00000489031
  • ENSP00000417210

Symbol
  • NEM10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.64
microRNA
0.53
tissue sample
0.52
biological process
0.49
gene perturbation
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.93   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.93   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
8.1
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (68)
1 – 10 of 68
KLHL40
Tbio
Novelty: 0.0432945
Score: 0.974
Data Source: STRINGDB
KLHL41
Tbio
Novelty: 0.03973182
Score: 0.853
Data Source: STRINGDB
KBTBD13
Tbio
Novelty: 0.09921158
Score: 0.797
Data Source: STRINGDB
FSD2
Tbio
Novelty: 0.1302271
Score: 0.763
Data Source: STRINGDB
SDR42E2
Tdark
Family: Enzyme
Novelty: 43
Score: 0.747
Data Source: STRINGDB
ADSSL1
Tbio
Family: Enzyme
Novelty: 0.0511949
Score: 0.726
Data Source: STRINGDB
FHOD1
Tbio
Novelty: 0.02593459
Score: 0.724
Data Source: STRINGDB
CRAMP1
Tdark
Novelty: 0.26519971
Score: 0.719
Data Source: STRINGDB
MYOZ2
Tbio
Novelty: 0.04557513
Score: 0.704
Data Source: STRINGDB
TNNT3
Tbio
Novelty: 0.0212335
Score: 0.703
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.93

PubMed score by year
PubTator Score  7.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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