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Tbio
ELP6
Elongator complex protein 6

Protein Summary
Description
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296149
  • ENSP00000296149
  • ENSG00000163832

Symbol
  • ATP1
  • C3orf75
  • TMEM103
  • C3orf75
  • TMEM103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
cell type or tissue
0.77
small molecule perturbation
0.68
transcription factor perturbation
0.68
histone modification site profile
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.48   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.48   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
2
2
82
sex hormone-binding globulin measurement
2
1
2
78.1
smoking status measurement
1
1
1
59.6
age at first birth measurement
1
1
1
46.1
heel bone mineral density
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
2
82
sex hormone-binding globulin measurement
2
78.1
smoking status measurement
1
59.6
age at first birth measurement
1
46.1
heel bone mineral density
1
29
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elongator acetyltransferase complex subunit 6
VGNC:1806
460335
Macaque
elongator acetyltransferase complex subunit 6
711423
Mouse
MGI:1919349
72341
Rat
RGD:1305478
363150
Dog
elongator acetyltransferase complex subunit 6
VGNC:49826
609199
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elongator acetyltransferase complex subunit 6
Macaque
elongator acetyltransferase complex subunit 6
Mouse
Rat
Dog
elongator acetyltransferase complex subunit 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q0PNE2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
FlyBase
Protein-Protein Interactions (71)
1 – 10 of 71
ELP5
Tbio
Novelty:  0.07212185
p_int:  0.999999964
p_ni:  8e-9
p_wrong:  2.8e-8
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
ZNF639
Tbio
Family:  TF
Novelty:  0.20063643
p_int:  0.999999957
p_ni:  1.8e-8
p_wrong:  2.5e-8
Score:  0.534
Data Source:  BioPlex,STRINGDB
ZBTB2
Tbio
Family:  TF
Novelty:  0.12299559
p_int:  0.999999886
p_ni:  1.13e-7
Score:  0.198
Data Source:  BioPlex,STRINGDB
ELP4
Tbio
Novelty:  0.03734233
p_int:  0.999994141
p_ni:  0.000005859
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PIPOX
Tbio
Family:  Enzyme
Novelty:  0.04107707
p_int:  0.999469181
p_ni:  0.000530819
Score:  0.864
Data Source:  BioPlex,STRINGDB
ZBTB25
Tbio
Family:  TF
Novelty:  0.0068423
p_int:  0.988770476
p_ni:  0.000001692
p_wrong:  0.011227832
Score:  0.534
Data Source:  BioPlex,STRINGDB
KLHL15
Tbio
Novelty:  0.54712519
p_int:  0.939526479
p_ni:  0.060473521
Score:  0.159
Data Source:  BioPlex,STRINGDB
LAMP1
Tbio
Novelty:  0.00067563
p_int:  0.933119134
p_ni:  0.066870226
p_wrong:  0.00001064
Score:  0.179
Data Source:  BioPlex,STRINGDB
GATD1
Tdark
Family:  Enzyme
Novelty:  0.40291197
p_int:  0.923782769
p_ni:  0.076217186
p_wrong:  4.6e-8
Data Source:  BioPlex
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.897770189
p_ni:  0.1022298
p_wrong:  1.1e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  79.48

PubMed score by year
PubTator Score  2.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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