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Tbio
FCHO2
F-BAR domain only protein 2

Protein Summary
Description
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000430046
  • ENSP00000393776
  • ENSG00000157107
  • ENST00000512348
  • ENSP00000427296
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
histone modification site profile
0.85
transcription factor
0.75
drug perturbation
0.71
microRNA
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.65   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.65   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
59
albumin:globulin ratio measurement
1
1
1
56.9
serum non-albumin protein measurement
1
1
1
56.7
red blood cell density measurement
1
1
1
38.9
mean platelet volume
1
1
1
35.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
59
albumin:globulin ratio measurement
1
56.9
serum non-albumin protein measurement
1
56.7
red blood cell density measurement
1
38.9
mean platelet volume
1
35.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FCH domain only 2
VGNC:4003
471520
Macaque
FCH domain only 2
702506
Mouse
MGI:3505790
218503
Rat
RGD:1565396
309129
Dog
FCH domain only 2
VGNC:40805
478094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FCH domain only 2
Macaque
FCH domain only 2
Mouse
Rat
Dog
FCH domain only 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q0JRZ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (23)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (151)
1 – 10 of 151
EPS15L1
Tbio
Novelty: 0.06929299
p_int: 0.999999995
p_ni: 5e-9
Score: 0.979
Data Source: BioPlex,STRINGDB
FCHO1
Tbio
Novelty: 0.10512826
p_int: 0.999999925
p_ni: 6.6e-8
p_wrong: 9e-9
Score: 0.924
Data Source: BioPlex,STRINGDB
DAB2
Tbio
Novelty: 0.00534123
p_int: 0.999999834
p_ni: 1.33e-7
p_wrong: 3.4e-8
Score: 0.993
Data Source: BioPlex,STRINGDB
AP2S1
Tbio
Novelty: 0.01931502
p_int: 0.999999488
p_ni: 8.2e-8
p_wrong: 4.3e-7
Score: 0.953
Data Source: BioPlex,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999999009
p_ni: 9.91e-7
Score: 0.959
Data Source: BioPlex,STRINGDB
SPC25
Tbio
Novelty: 0.26354244
p_int: 0.999993835
p_ni: 0.000006165
Score: 0.191
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.999990372
p_ni: 0.000009626
p_wrong: 2e-9
Score: 0.204
Data Source: BioPlex,STRINGDB
MACC1
Tbio
Novelty: 0.00737376
p_int: 0.991718902
p_ni: 0.008280304
p_wrong: 7.94e-7
Data Source: BioPlex
EPS15
Tbio
Novelty: 0.00451447
Score: 0.986
Data Source: STRINGDB
TRIP10
Tbio
Novelty: 0.01553463
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.65

PubMed score by year
PubTator Score  8.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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