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Tbio
NIPAL4
Magnesium transporter NIPA4

Protein Summary
Description
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive congenital ichthyosis. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311946
  • ENSP00000311687
  • ENSG00000172548
  • ENST00000435489
  • ENSP00000406456

Symbol
  • ICHN
  • NIPA4
  • ARCI6
  • ICHYN
  • ICHTHYIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.76
tissue sample
0.63
histone modification site profile
0.54
tissue
0.52
cell type or tissue
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.1   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.1   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (35)
1 – 10 of 35
CYP4F22
Tbio
Novelty:  0.01907586
Score:  0.917
Data Source:  STRINGDB
ALOXE3
Tbio
Family:  Enzyme
Novelty:  0.02560954
Score:  0.872
Data Source:  STRINGDB
ALOX12B
Tbio
Family:  Enzyme
Novelty:  0.02778552
Score:  0.86
Data Source:  STRINGDB
ABCA12
Tbio
Family:  Transporter
Novelty:  0.00594736
Score:  0.824
Data Source:  STRINGDB
PNPLA1
Tbio
Family:  Enzyme
Novelty:  0.03127922
Score:  0.813
Data Source:  STRINGDB
TGM1
Tchem
Family:  Enzyme
Novelty:  0.00103799
Score:  0.808
Data Source:  STRINGDB
LIPN
Tbio
Family:  Enzyme
Novelty:  0.00135912
Score:  0.78
Data Source:  STRINGDB
CERS3
Tbio
Family:  TF
Novelty:  0.038629
Score:  0.753
Data Source:  STRINGDB
GNG13
Tbio
Novelty:  0.13011919
Score:  0.715
Data Source:  STRINGDB
PI4K2B
Tbio
Family:  Enzyme
Novelty:  0.19272599
Score:  0.714
Data Source:  STRINGDB
Pathways (2)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
Transport of small molecules
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
2
2
93.6
peak expiratory flow
1
2
2
88.3
forced expiratory volume
1
2
2
88.2
3
5
0
1.1
87.6
mean platelet volume
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
93.6
peak expiratory flow
2
88.3
forced expiratory volume
2
88.2
0
1.1
87.6
mean platelet volume
1
53.7
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NIPA like domain containing 4
VGNC:6952
100613247
Macaque
NIPA like domain containing 4
715106
Mouse
MGI:2444671
214112
Rat
RGD:1309452
303070
Dog
NIPA like domain containing 4
VGNC:43818
489157
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NIPA like domain containing 4
Macaque
NIPA like domain containing 4
Mouse
Rat
Dog
NIPA like domain containing 4
Publication Statistics
PubMed Score 22.10
PubMed score by year
PubTator Score 11.34
PubTator score by year