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Tchem
EP300
Histone acetyltransferase p300

Protein Summary
Description
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263253
  • ENSP00000263253
  • ENSG00000100393

Symbol
  • P300
  • p300
  • KAT3B
  • MKHK2
  • RSTS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
viral protein
1
virus
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1578.07   (req: < 5)
Gene RIFs: 336   (req: <= 3)
Antibodies: 969   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1578.07   (req: >= 5)
Gene RIFs: 336   (req: > 3)
Antibodies: 969   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 87
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (23)
1 – 10 of 23
CHEMBL297453
chemical structure image
CHEMBL140
chemical structure image
CHEMBL3814752
chemical structure image
CHEMBL295316
chemical structure image
CHEMBL1331211
chemical structure image
CHEMBL3774655
chemical structure image
CHEMBL3622373
chemical structure image
CHEMBL3968533
chemical structure image
anacardic acid
chemical structure image
garcinol
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, hip
1
1
0
5.9
82.8
risk-taking behaviour
2
2
2
64.1
insomnia measurement
1
1
0
1
52.8
red blood cell distribution width
1
1
1
36.5
mood instability measurement
1
1
0
6.4
30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, hip
0
5.9
82.8
risk-taking behaviour
2
64.1
insomnia measurement
0
1
52.8
red blood cell distribution width
1
36.5
mood instability measurement
0
6.4
30
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E1A binding protein p300
VGNC:5978
458862
Macaque
E1A binding protein p300
706258
Mouse
MGI:1276116
328572
Dog
zinc finger CCCH-type containing 7B
474490
Horse
E1A binding protein p300
VGNC:17605
100055626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E1A binding protein p300
Macaque
E1A binding protein p300
Mouse
Dog
zinc finger CCCH-type containing 7B
Horse
E1A binding protein p300
Protein Structure (28 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q09472-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 28
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (212)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 100
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Attenuation phase
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activation of the TFAP2 (AP-2) family of transcription factors
Attenuation phase
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (94)
Items per page:
10
1 – 10 of 28
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (1000)
1 – 10 of 1000
CITED1
Tbio
Novelty: 0.01956689
p_int: 0.999999993
p_ni: 7e-9
Score: 0.954
Data Source: BioPlex,Reactome,STRINGDB
CTGF
Tbio
Novelty: 0.0004346
p_int: 0.999999842
p_ni: 1.58e-7
Score: 0.462
Data Source: BioPlex,STRINGDB
C3orf62
Tdark
Novelty: 1.85670012
p_int: 0.999999774
p_ni: 2.26e-7
Score: 0.534
Data Source: BioPlex,STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.999999718
p_ni: 2.82e-7
Score: 0.816
Data Source: BioPlex,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.999997783
p_ni: 0.000002208
p_wrong: 9e-9
Score: 0.822
Data Source: BioPlex,STRINGDB
SPATA1
Tdark
p_int: 0.998408303
p_ni: 0.001591695
p_wrong: 2e-9
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.997045075
p_ni: 0.002954763
p_wrong: 1.63e-7
Score: 0.944
Data Source: BioPlex,Reactome,STRINGDB
CDC20
Tbio
Novelty: 0.00197887
p_int: 0.996406568
p_ni: 0.003593375
p_wrong: 5.7e-8
Score: 0.767
Data Source: BioPlex,STRINGDB
CNOT3
Tbio
Novelty: 0.02463568
p_int: 0.985891876
p_ni: 0.014108013
p_wrong: 1.11e-7
Score: 0.292
Data Source: BioPlex,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1578.07

PubMed score by year
PubTator Score  3785.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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