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Tchem
EP300
Histone acetyltransferase p300

Protein Summary
Description
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263253
  • ENSP00000263253
  • ENSG00000100393

Symbol
  • P300
  • p300
  • KAT3B
  • MKHK2
  • RSTS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
viral protein
1
virus
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1633.51   (req: < 5)
Gene RIFs: 336   (req: <= 3)
Antibodies: 969   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1633.51   (req: >= 5)
Gene RIFs: 336   (req: > 3)
Antibodies: 969   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 87
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 95
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (95)
epigallocatechin gallate
Rendered image for epigallocatechin gallate
curcumin
Rendered image for curcumin
CHEMBL4173488
Rendered image for CHEMBL4173488
CHEMBL4436408
Rendered image for CHEMBL4436408
Mivebresib
Rendered image for Mivebresib
US9458145, 1020-18
Rendered image for US9458145, 1020-18
CHEMBL4171228
Rendered image for CHEMBL4171228
plumbagin
Rendered image for plumbagin
I-CBP112
Rendered image for I-CBP112
CHEMBL4648912
Rendered image for CHEMBL4648912
Protein-Protein Interactions (1000)
CITED1
Tbio
Novelty:  0.01956689
p_int:  0.999999993
p_ni:  7e-9
Score:  0.954
Data Source:  BioPlex,Reactome,STRINGDB
CTGF
Tbio
Novelty:  0.0004346
p_int:  0.999999842
p_ni:  1.58e-7
Score:  0.462
Data Source:  BioPlex,STRINGDB
C3orf62
Tdark
Novelty:  1.85670012
p_int:  0.999999774
p_ni:  2.26e-7
Score:  0.534
Data Source:  BioPlex,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999999718
p_ni:  2.82e-7
Score:  0.816
Data Source:  BioPlex,STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  0.999997783
p_ni:  0.000002208
p_wrong:  9e-9
Score:  0.822
Data Source:  BioPlex,STRINGDB
SPATA1
Tdark
p_int:  0.998408303
p_ni:  0.001591695
p_wrong:  2e-9
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.997045075
p_ni:  0.002954763
p_wrong:  1.63e-7
Score:  0.944
Data Source:  BioPlex,Reactome,STRINGDB
CDC20
Tbio
Novelty:  0.00197887
p_int:  0.996406568
p_ni:  0.003593375
p_wrong:  5.7e-8
Score:  0.767
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.985891876
p_ni:  0.014108013
p_wrong:  1.11e-7
Score:  0.292
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
Pathways (212)
Activation of HOX genes during differentiation (R-HSA-5619507)

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Find Similar Targets
Items per page:
1 – 5 of 100
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Attenuation phase
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activation of the TFAP2 (AP-2) family of transcription factors
Attenuation phase
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (94)
Find Similar Targets
Items per page:
10
1 – 10 of 28
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
6
2
1
96.9
neuroticism measurement
5
6
3
7
89.2
1
2
0
5.9
88.5
risk-taking behaviour
2
4
4
84.3
eosinophil count
3
2
3
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
96.9
neuroticism measurement
3
7
89.2
0
5.9
88.5
risk-taking behaviour
4
84.3
eosinophil count
3
83.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E1A binding protein p300
VGNC:5978
458862
Macaque
E1A binding protein p300
706258
Mouse
MGI:1276116
328572
Dog
zinc finger CCCH-type containing 7B
474490
Horse
E1A binding protein p300
VGNC:17605
100055626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E1A binding protein p300
Macaque
E1A binding protein p300
Mouse
Dog
zinc finger CCCH-type containing 7B
Horse
E1A binding protein p300
Publication Statistics
PubMed Score 1633.51
PubMed score by year
PubTator Score 3785.47
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title