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Tclin
KCNA1
Potassium voltage-gated channel subfamily A member 1

Protein Summary
Description
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382545
  • ENSP00000371985
  • ENSG00000111262

Symbol
  • EA1
  • MK1
  • AEMK
  • HBK1
  • HUK1
  • MBK1
  • RBK1
  • KV1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
microRNA
0.89
gene perturbation
0.85
molecular function
0.84
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 550.87   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 550.87   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (293)
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.995
Data Source:  STRINGDB
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.992
Data Source:  STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.973
Data Source:  STRINGDB
CNTNAP1
Tbio
Novelty:  0.00618741
Score:  0.886
Data Source:  STRINGDB
CACNA1A
Tchem
Family:  IC
Novelty:  0.00069217
Score:  0.798
Data Source:  STRINGDB
SCN2A
Tclin
Family:  IC
Novelty:  0.0007317
Score:  0.792
Data Source:  STRINGDB
KCNA3
Tclin
Family:  IC
Novelty:  0.00169224
Score:  0.789
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.781
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (49)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily A member 1
VGNC:13160
466928
Mouse
MGI:96654
16485
Rat
RGD:2949
24520
Dog
potassium voltage-gated channel subfamily A member 1
VGNC:42227
486732
Horse
potassium voltage-gated channel subfamily A member 1
VGNC:19260
100051648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily A member 1
Mouse
Rat
Dog
potassium voltage-gated channel subfamily A member 1
Horse
potassium voltage-gated channel subfamily A member 1
Publication Statistics
PubMed Score 550.87
PubMed score by year
PubTator Score 334.67
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title