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Tclin
ABCC8
ATP-binding cassette sub-family C member 8

Protein Summary
Description
Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302539
  • ENSP00000303960
  • ENSG00000006071
  • ENST00000389817
  • ENSP00000374467
  • ENST00000612903
  • ENSP00000483031
  • ENST00000643878
  • ENSP00000495271
  • ENST00000644542
  • ENSP00000495532

Symbol
  • HRINS
  • SUR
  • SUR1
  • HI
  • SUR
  • HHF1
  • MRP8
  • PHHI
  • SUR1
  • ABC36
  • HRINS
  • TNDM2
  • SUR1delta2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
co-expressed gene
0.99
protein domain
0.92
phenotype
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1231.43   (req: < 5)
Gene RIFs: 168   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1231.43   (req: >= 5)
Gene RIFs: 168   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16
Approved Drugs (16)
1 – 10 of 16
glibenclamide
chemical structure image
tolazamide
chemical structure image
gliclazide
chemical structure image
glipizide
chemical structure image
gliquidone
chemical structure image
glisoxepide
chemical structure image
glibornuride
chemical structure image
chlorpropamide
chemical structure image
tolbutamide
chemical structure image
carbutamide
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
1
1.5
97.3
sex hormone-binding globulin measurement
1
1
1
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.5
97.3
sex hormone-binding globulin measurement
1
74
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 8
VGNC:11253
451056
Macaque
ATP binding cassette subfamily C member 8
654490
Mouse
MGI:1352629
20927
Rat
RGD:3786
25559
Dog
ATP binding cassette subfamily C member 8
VGNC:37443
485402
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 8
Macaque
ATP binding cassette subfamily C member 8
Mouse
Rat
Dog
ATP binding cassette subfamily C member 8
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q09428-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ATP sensitive Potassium channels
Reactome
Defective ABCC8 can cause hypoglycemias and hyperglycemias
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ATP sensitive Potassium channels
Defective ABCC8 can cause hypoglycemias and hyperglycemias
Disease
Disorders of transmembrane transporters
Gene Ontology Terms (36)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (126)
1 – 10 of 126
KCNJ11
Tclin
Family: IC
Novelty: 0.00068183
Score: 0.998
Data Source: Reactome,STRINGDB
KCNJ8
Tbio
Family: IC
Novelty: 0.00369886
Score: 0.995
Data Source: Reactome,STRINGDB
RAPGEF4
Tchem
Novelty: 0.00235788
Score: 0.983
Data Source: STRINGDB
RAPGEF3
Tchem
Novelty: 0.00199705
Score: 0.962
Data Source: STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
Score: 0.91
Data Source: STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
Score: 0.905
Data Source: STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.902
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.805
Data Source: STRINGDB
TRPM4
Tchem
Family: IC
Novelty: 0.00423106
Score: 0.802
Data Source: STRINGDB
GCK
Tchem
Family: Kinase
Novelty: 0.00112778
Score: 0.76
Data Source: STRINGDB
Publication Statistics
PubMed Score  1231.43

PubMed score by year
PubTator Score  805.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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