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Tbio
NCBP1
Nuclear cap-binding protein subunit 1

Protein Summary
Description
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375147
  • ENSP00000364289
  • ENSG00000136937

Symbol
  • CBP80
  • NCBP
  • NCBP
  • Sto1
  • CBP80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
disease perturbation
0.9
transcription factor perturbation
0.88
virus perturbation
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.22   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.22   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (60)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 56
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Axon guidance
Developmental Biology
Disease
Diseases of signal transduction
Gene Ontology Terms (36)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (623)
1 – 10 of 623
SNIP1
Tbio
Novelty: 0.01865867
p_int: 0.934654675
p_ni: 0.065345325
Score: 0.707
Data Source: BioPlex,STRINGDB
GSPT2
Tbio
Family: Enzyme
Novelty: 0.08140512
p_int: 0.913217857
p_ni: 0.086782143
Score: 0.95
Data Source: BioPlex,STRINGDB
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.86574168
p_ni: 0.13425832
Data Source: BioPlex
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.864528932
p_ni: 0.135471068
Score: 0.972
Data Source: BioPlex,STRINGDB
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.842074606
p_ni: 0.157925394
Data Source: BioPlex
LUC7L
Tbio
Novelty: 0.05748021
p_int: 0.824902355
p_ni: 0.175097645
Score: 0.506
Data Source: BioPlex,STRINGDB
THOC2
Tbio
Novelty: 0.02886456
Score: 0.999
Data Source: STRINGDB
NCBP2
Tbio
Novelty: 0.01426734
Score: 0.999
Data Source: Reactome,STRINGDB
NELFE
Tbio
Novelty: 0.02136256
Score: 0.999
Data Source: Reactome,STRINGDB
THOC5
Tbio
Novelty: 0.04618391
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  74.22

PubMed score by year
PubTator Score  48.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer