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Tchem
DMPK
Myotonin-protein kinase

Protein Classes
Protein Summary
Description
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291270
  • ENSP00000291270
  • ENSG00000104936
  • ENST00000343373
  • ENSP00000345997
  • ENST00000354227
  • ENSP00000346168
  • ENST00000447742
  • ENSP00000413417
  • ENST00000458663
  • ENSP00000401753
  • ENST00000618091
  • ENSP00000482746

Symbol
  • DM1PK
  • MDPK
  • DM
  • DM1
  • DMK
  • MDPK
  • DM1PK
  • MT-PK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.92
biological term
0.76
co-expressed gene
0.76
tissue sample
0.65


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.06   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.06   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DM1 protein kinase
VGNC:2395
456139
Macaque
DM1 protein kinase
715328
Mouse
MGI:94906
13400
Rat
RGD:1309825
308405
Dog
DM1 protein kinase
VGNC:40001
484436
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DM1 protein kinase
Macaque
DM1 protein kinase
Mouse
Rat
Dog
DM1 protein kinase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q09013-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion homeostasis
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion homeostasis
Muscle contraction
Protein-Protein Interactions (68)
1 – 10 of 68
PLN
Tbio
Novelty: 0.01615063
Score: 0.946
Data Source: Reactome,STRINGDB
CNBP
Tbio
Novelty: 0.00404247
Score: 0.896
Data Source: STRINGDB
CELF1
Tbio
Novelty: 0.00666261
Score: 0.844
Data Source: STRINGDB
MBNL1
Tbio
Novelty: 0.00441241
Score: 0.835
Data Source: STRINGDB
CCT3
Tbio
Novelty: 0.01642521
Score: 0.745
Data Source: STRINGDB
HSPB2
Tbio
Novelty: 0.00103909
Score: 0.744
Data Source: STRINGDB
CLCN1
Tbio
Family: IC
Novelty: 0.00287764
Score: 0.743
Data Source: STRINGDB
YIPF7
Tdark
Novelty: 0.07555804
Score: 0.731
Data Source: STRINGDB
SIX5
Tbio
Family: TF
Novelty: 0.01599301
Score: 0.714
Data Source: STRINGDB
MBNL2
Tbio
Novelty: 0.02398556
Score: 0.649
Data Source: STRINGDB
Publication Statistics
PubMed Score  372.06

PubMed score by year
PubTator Score  1270.43

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer