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Tchem
DMPK
Myotonin-protein kinase

Protein Summary
Description
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291270
  • ENSP00000291270
  • ENSG00000104936
  • ENST00000343373
  • ENSP00000345997
  • ENST00000354227
  • ENSP00000346168
  • ENST00000447742
  • ENSP00000413417
  • ENST00000458663
  • ENSP00000401753
  • ENST00000618091
  • ENSP00000482746

Symbol
  • DM1PK
  • MDPK
  • DM
  • DM1
  • DMK
  • MDPK
  • DM1PK
  • MT-PK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.92
biological term
0.76
co-expressed gene
0.76
tissue sample
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425.55   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425.55   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0