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Tbio
NSUN2
tRNA (cytosine(34)-C(5))-methyltransferase

Protein Summary
Description
RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity. This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264670
  • ENSP00000264670
  • ENSG00000037474
  • ENST00000506139
  • ENSP00000420957

Symbol
  • SAKI
  • TRM4
  • MISU
  • MRT5
  • SAKI
  • TRM4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.98
transcription factor binding site profile
0.89
histone modification site profile
0.87
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.6   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.6   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (242)
UBE3A
Tbio
Family:  Enzyme
Novelty:  0.00149368
p_int:  0.999999853
p_ni:  1.47e-7
Score:  0.207
Data Source:  BioPlex,STRINGDB
MPP6
Tbio
Novelty:  0.08883057
p_int:  0.999992487
p_ni:  0.000007513
Score:  0.599
Data Source:  BioPlex,STRINGDB
METTL3
Tbio
Family:  Enzyme
Novelty:  0.00420954
p_int:  0.998610935
p_ni:  0.001389064
Score:  0.647
Data Source:  BioPlex,STRINGDB
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.987883699
p_ni:  0.012116301
Data Source:  BioPlex
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
p_int:  0.959191173
p_ni:  0.017046984
p_wrong:  0.023761844
Score:  0.539
Data Source:  BioPlex,STRINGDB
NRP1
Tchem
Novelty:  0.00153628
p_int:  0.923567159
p_ni:  0.076432841
Data Source:  BioPlex
LIN7C
Tbio
Novelty:  0.06778878
p_int:  0.923166624
p_ni:  0.076833376
Score:  0.305
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.901086928
p_ni:  0.098913072
Score:  0.173
Data Source:  BioPlex,STRINGDB
LIN7A
Tbio
Novelty:  0.0202389
p_int:  0.85214799
p_ni:  0.147852009
Score:  0.241
Data Source:  BioPlex,STRINGDB
CNDP2
Tbio
Family:  Enzyme
Novelty:  0.00157228
p_int:  0.8314518
p_ni:  0.1685482
Score:  0.239
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
1
1
0
1.1
21.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
0
1.1
21.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NOP2/Sun RNA methyltransferase family member 2
VGNC:7092
461711
Macaque
NOP2/Sun RNA methyltransferase family member 2
694987
Mouse
MGI:107252
28114
Rat
RGD:1311954
361191
Dog
NOP2/Sun RNA methyltransferase family member 2
VGNC:43990
478625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NOP2/Sun RNA methyltransferase family member 2
Macaque
NOP2/Sun RNA methyltransferase family member 2
Mouse
Rat
Dog
NOP2/Sun RNA methyltransferase family member 2
Publication Statistics
PubMed Score 120.60
PubMed score by year
PubTator Score 36.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title