Tbio NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase

Protein Summary

Description

RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity. This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q08J23
• A8K529
• B2RNR4
• B3KP09
• B4DQW2
• G3V1R4
• Q9BVN4
• Q9H858
• Q9NXD9

Gene Name

• NSUN2

Ensembl ID

• ENST00000264670
• ENSP00000264670
• ENSG00000037474
• ENST00000506139
• ENSP00000420957

Symbol

• SAKI
• TRM4
• MISU
• MRT5
• SAKI
• TRM4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	0.98
transcription factor binding site profile	0.89
histone modification site profile	0.87
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Trna (Cytosine(34)-c(5))-methyltransferase

Protein / Nucleic Acid Binding / Trna (Cytosine(34)-c(5))-methyltransferase

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Trna (Cytosine(34)-c(5))-methyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.6   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.6   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0