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Tbio
SIGLEC14
Sialic acid-binding Ig-like lectin 14

Protein Summary
Description
Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360844
  • ENSP00000354090
  • ENSG00000254415
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
microRNA
0.79
tissue sample
0.71
tissue
0.67
cell line
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.14   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.14   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (77)
1 – 10 of 77
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.978
Data Source:  Reactome,STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.938
Data Source:  STRINGDB
CLEC5A
Tbio
Novelty:  0.01710591
Score:  0.931
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.921
Data Source:  STRINGDB
CEACAM8
Tbio
Novelty:  0.00370138
Score:  0.92
Data Source:  STRINGDB
SLC11A1
Tbio
Family:  Transporter
Novelty:  0.00121416
Score:  0.918
Data Source:  STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.917
Data Source:  STRINGDB
SIRPA
Tbio
Family:  Enzyme
Novelty:  0.0021102
Score:  0.917
Data Source:  STRINGDB
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.917
Data Source:  STRINGDB
CLEC12A
Tbio
Novelty:  0.01478908
Score:  0.917
Data Source:  STRINGDB
Pathways (4)
DAP12 interactions (R-HSA-2172127)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DAP12 interactions
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
DAP12 interactions
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
3
76.7
eosinophil count
1
1
1
69.5
neutrophil percentage of leukocytes
1
1
1
59.5
eosinophil percentage of leukocytes
1
1
1
56.4
mean corpuscular volume
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
76.7
eosinophil count
1
69.5
neutrophil percentage of leukocytes
1
59.5
eosinophil percentage of leukocytes
1
56.4
mean corpuscular volume
1
38.8
Find similar targets by:
Publication Statistics
PubMed Score 13.14
PubMed score by year
PubTator Score 11.80
PubTator score by year