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Tbio
VAC14
Protein VAC14 homolog

Protein Classes
Protein Summary
Description
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. This gene encodes a scaffold protein that is a component of the PIKfyve protein kinase complex. This complex is responsible for the synthesis of phosphatidylinositol 3,5-bisphosphate, an important component of cellular membranes, from phosphatidylinositol 3-phosphate. Mice lacking a functional copy of this gene exhibit severe neurodegeneration. Mutations in the human gene have been identified in patients with a childhood onset progressive neurological disorder characterized by impaired movement, dystonia, and striatal abno ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261776
  • ENSP00000261776
  • ENSG00000103043
  • ENST00000536184
  • ENSP00000439284

Symbol
  • TAX1BP2
  • TRX
  • TRX
  • TAX1BP2
  • ArPIKfyve
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor binding site profile
0.84
kinase perturbation
0.81
transcription factor
0.78
interacting protein
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.1   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.1   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
1
3
81.6
self reported educational attainment
1
1
1
73.6
intelligence
1
1
0
5.5
55.2
red blood cell density measurement
1
1
1
53.6
hemoglobin measurement
1
1
1
51.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
81.6
self reported educational attainment
1
73.6
intelligence
0
5.5
55.2
red blood cell density measurement
1
53.6
hemoglobin measurement
1
51.9
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the Golgi membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the Golgi membrane
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (94)
1 – 10 of 94
FIG4
Tbio
Family: Enzyme
Novelty: 0.00742268
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PIKFYVE
Tchem
Family: Kinase
Novelty: 0.00441336
p_int: 0.999998328
p_ni: 0.000001662
p_wrong: 1e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ERGIC2
Tbio
Novelty: 0.08610944
p_int: 0.998142855
p_ni: 0.001857145
Score: 0.15
Data Source: BioPlex,STRINGDB
ME1
Tchem
Novelty: 0.00553719
p_int: 0.996389288
p_ni: 0.003610656
p_wrong: 5.6e-8
Data Source: BioPlex
LNPK
Tbio
Novelty: 0.07736762
p_int: 0.991354581
p_ni: 0.008645418
p_wrong: 1e-9
Data Source: BioPlex
ZMPSTE24
Tbio
Family: Enzyme
Novelty: 0.0027993
p_int: 0.990638547
p_ni: 0.009361448
p_wrong: 5e-9
Data Source: BioPlex
CLCN7
Tchem
Family: IC
Novelty: 0.00764796
p_int: 0.987457352
p_ni: 0.012538876
p_wrong: 0.000003772
Score: 0.359
Data Source: BioPlex,STRINGDB
ANK1
Tbio
Novelty: 0.00225305
p_int: 0.978973006
p_ni: 0.021026994
Score: 0.768
Data Source: BioPlex,STRINGDB
MAVS
Tbio
Novelty: 0.00241215
p_int: 0.975444484
p_ni: 0.024555475
p_wrong: 4.1e-8
Data Source: BioPlex
RAB21
Tbio
Family: Enzyme
Novelty: 0.03221825
p_int: 0.957429052
p_ni: 0.042570947
Data Source: BioPlex
Publication Statistics
PubMed Score  39.10

PubMed score by year
PubTator Score  27.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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