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Tbio
ACSM2A
Acyl-coenzyme A synthetase ACSM2A, mitochondrial

Protein Summary
Description
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity). This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219054
  • ENSP00000219054
  • ENSG00000183747
  • ENST00000396104
  • ENSP00000379411
  • ENST00000573854
  • ENSP00000459451
  • ENST00000575690
  • ENSP00000460349

Symbol
  • ACSM2
  • MACS2
  • ACSM2
  • A-923A4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
cell type or tissue
0.67
pathway
0.67
virus perturbation
0.59
cell line
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.88   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.88   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
2
2
81.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
81.6
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
acyl-coenzyme A synthetase ACSM2B, mitochondrial
696244
Mouse
MGI:2385289
233799
Rat
Dog
acyl-coenzyme A synthetase ACSM2B, mitochondrial
479822
Cow
acyl-CoA synthetase medium-chain family member 2B
512227
Species
Name
OMA
EggNOG
Inparanoid
Macaque
acyl-coenzyme A synthetase ACSM2B, mitochondrial
Mouse
Rat
Dog
acyl-coenzyme A synthetase ACSM2B, mitochondrial
Cow
acyl-CoA synthetase medium-chain family member 2B
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q08AH3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Amino Acid conjugation (R-HSA-156587)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino Acid conjugation
Reactome
Biological oxidations
Reactome
Conjugation of carboxylic acids
Reactome
Conjugation of salicylate with glycine
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Amino Acid conjugation
Biological oxidations
Conjugation of carboxylic acids
Conjugation of salicylate with glycine
Metabolism
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (12)
1 – 10 of 12
ACADS
Tbio
Family: Enzyme
Novelty: 0.00841051
Score: 0.913
Data Source: STRINGDB
CTNNBL1
Tbio
Novelty: 0.0189038
Score: 0.778
Data Source: STRINGDB
HOMER1
Tbio
Novelty: 0.00264721
Score: 0.669
Data Source: STRINGDB
RNF25
Tbio
Family: Enzyme
Novelty: 0.08945219
Score: 0.656
Data Source: STRINGDB
CTCF
Tbio
Family: TF
Novelty: 0.00085923
Score: 0.538
Data Source: STRINGDB
PALMD
Tbio
Novelty: 0.11193793
Score: 0.51
Data Source: STRINGDB
CS
Tbio
Family: Enzyme
Novelty: 0.00154214
Score: 0.454
Data Source: STRINGDB
RNMT
Tbio
Family: Enzyme
Novelty: 0.00880207
Score: 0.453
Data Source: STRINGDB
MDFIC
Tbio
Novelty: 0.00447926
Score: 0.441
Data Source: STRINGDB
ALDH18A1
Tbio
Family: Enzyme
Novelty: 0.00301673
Score: 0.437
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.88

PubMed score by year
PubTator Score  4.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer