Tdark MZT1 Mitotic-spindle organizing protein 1

Protein Summary

Description

Required for gamma-tubulin complex recruitment to the centrosome.

Uniprot Accession IDs

• Q08AG7
• Q5W0P5

Gene Name

• MZT1

Ensembl ID

• ENST00000377818
• ENSP00000367049
• ENSG00000204899

Symbol

• C13orf37
• MOZART1
• MOZART1
• C13orf37

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
transcription factor binding site profile	0.69
virus perturbation	0.68
cell type or tissue	0.66
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.59   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.59   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (120)

Explore Interacting Targets

1 – 10 of 120

• See Interactions on String-DB

TUBGCP5

Tbio

Novelty:  0.04863776

p_int:  0.999999567

p_ni:  4.32e-7

p_wrong:  1e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

MZT2A

Tdark

Novelty:  1.66535264

p_int:  0.999998418

p_ni:  2.95e-7

p_wrong:  0.000001288

Score:  0.997

Data Source:  BioPlex,STRINGDB

TUBGCP3

Tbio

Novelty:  0.0221126

p_int:  0.999972335

p_ni:  0.000027665

Score:  0.999

Data Source:  BioPlex,STRINGDB

TUBGCP6

Tbio

Novelty:  0.05801955

p_int:  0.999940655

p_ni:  0.000059345

Score:  0.999

Data Source:  BioPlex,STRINGDB

PCNT

Tbio

Novelty:  0.00369505

p_int:  0.999939463

p_ni:  0.000060537

Score:  0.948

Data Source:  BioPlex,STRINGDB

TUBGCP4

Tbio

Novelty:  0.04549455

p_int:  0.999903982

p_ni:  0.000095682

p_wrong:  3.35e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

TUBGCP2

Tbio

Novelty:  0.01856674

p_int:  0.999436514

p_ni:  0.000563486

Score:  0.997

Data Source:  BioPlex,STRINGDB

MZT2B

Tdark

Novelty:  0.69469786

p_int:  0.999395757

p_ni:  0.000602022

p_wrong:  0.000002221

Score:  0.998

Data Source:  BioPlex,STRINGDB

TUBG1

Tbio

Novelty:  0.02252882

p_int:  0.997280091

p_ni:  0.002719909

Score:  0.999

Data Source:  BioPlex,STRINGDB

NME7

Tbio

Family:  Enzyme

Novelty:  0.08546782

p_int:  0.994880374

p_ni:  0.005118762

p_wrong:  8.64e-7

Score:  0.995

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (9)

Cell Cycle (R-HSA-1640170)

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5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Centrosome maturation	81 targets	R-HSA-380287
Reactome	G2/M Transition	184 targets	R-HSA-69275
Reactome	M Phase	350 targets	R-HSA-68886

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Centrosome maturation	81 targets	R-HSA-380287
G2/M Transition	184 targets	R-HSA-69275
M Phase	350 targets	R-HSA-68886

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (1)

Components (7)

Processes (4)

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1 – 1 of 1

GO Term	Evidence	Assigned by
gamma-tubulin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean reticulocyte volume	EFO_0010701	1	1	1		71.2
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		32.9
testosterone measurement	EFO_0004908	1	1	1		6.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean reticulocyte volume	EFO_0010701	1		71.2
mean corpuscular hemoglobin concentration	EFO_0004528	1		32.9
testosterone measurement	EFO_0004908	1		6.6

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
mean corpuscular hemoglobin concentration
mean reticulocyte volume
testosterone measurement

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitotic spindle organizing protein 1	VGNC:5083	735745
Mouse	mitotic spindle organizing protein 1	MGI:1924039	76789
Rat	mitotic spindle organizing protein 1	RGD:1592140	692032
Dog	mitotic spindle organizing protein 1	VGNC:43595	100683696
Horse	mitotic-spindle organizing protein 1		100049899

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitotic spindle organizing protein 1
Mouse	mitotic spindle organizing protein 1
Rat	mitotic spindle organizing protein 1
Dog	mitotic spindle organizing protein 1
Horse	mitotic-spindle organizing protein 1

Publication Statistics

PubMed Score 18.59

PubMed score by year

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PubTator Score 7.00

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (2)

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10

0 of 0

PMID	Year	Title