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Tbio
SPIRE1
Protein spire homolog 1

Protein Summary
Description
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 1174782 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409402
  • ENSP00000387266
  • ENSG00000134278
  • ENST00000410092
  • ENSP00000387226
  • ENST00000440472
  • ENSP00000404752
  • ENST00000453447
  • ENSP00000407050

Symbol
  • KIAA1135
  • SPIR1
  • Spir-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
ligand (protein) perturbation
0.83
microRNA
0.82
kinase perturbation
0.81
histone modification site profile
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.01   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.01   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
49.5
pulse pressure measurement
1
1
1
47.7
hematocrit
1
1
1
42.3
hemoglobin measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
49.5
pulse pressure measurement
1
47.7
hematocrit
1
42.3
hemoglobin measurement
1
29
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spire type actin nucleation factor 1
VGNC:7332
468603
Mouse
MGI:1915416
68166
Rat
RGD:1305892
307348
Dog
spire type actin nucleation factor 1
VGNC:46748
490562
Horse
spire type actin nucleation factor 1
VGNC:23525
100050392
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spire type actin nucleation factor 1
Mouse
Rat
Dog
spire type actin nucleation factor 1
Horse
spire type actin nucleation factor 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q08AE8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (47)
1 – 10 of 47
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999999977
p_ni:  1.3e-8
p_wrong:  1e-8
Score:  0.671
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.999999862
p_ni:  1.38e-7
Score:  0.45
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999998743
p_ni:  5.92e-7
p_wrong:  6.64e-7
Score:  0.537
Data Source:  BioPlex,STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.902359591
p_ni:  0.000031634
p_wrong:  0.097608776
Score:  0.366
Data Source:  BioPlex,STRINGDB
FMN2
Tbio
Novelty:  0.02031944
Score:  0.977
Data Source:  STRINGDB
MYO5B
Tbio
Novelty:  0.01302142
Score:  0.871
Data Source:  STRINGDB
MYO5A
Tbio
Novelty:  0.00373224
Score:  0.817
Data Source:  STRINGDB
FMN1
Tbio
Novelty:  0.00130542
Score:  0.797
Data Source:  STRINGDB
MYO5C
Tbio
Novelty:  0.05680943
Score:  0.732
Data Source:  STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
Score:  0.573
Data Source:  STRINGDB
Publication Statistics
PubMed Score  15.01

PubMed score by year
PubTator Score  9.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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