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Tbio
RBL2
Retinoblastoma-like protein 2

Protein Summary
Description
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262133
  • ENSP00000262133
  • ENSG00000103479

Symbol
  • RB2
  • Rb2
  • P130
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.95
protein domain
0.85
kinase
0.83
transcription factor binding site profile
0.82
viral protein
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 829.96   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 432   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 829.96   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 432   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
3
0
7
96
cognitive function measurement
3
1
3
94.4
self reported educational attainment
1
1
1
88.6
BMI-adjusted waist-hip ratio
1
1
1
79.7
lifestyle measurement
1
1
1
77.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
7
96
cognitive function measurement
3
94.4
self reported educational attainment
1
88.6
BMI-adjusted waist-hip ratio
1
79.7
lifestyle measurement
1
77.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RB transcriptional corepressor like 2
VGNC:48994
467978
Mouse
MGI:105085
19651
Rat
RGD:3541
81758
Dog
RB transcriptional corepressor like 2
VGNC:45403
478127
Horse
RB transcriptional corepressor like 2
VGNC:22230
100060431
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RB transcriptional corepressor like 2
Mouse
Rat
Dog
RB transcriptional corepressor like 2
Horse
RB transcriptional corepressor like 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q08999-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (64)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin D associated events in G1
Reactome
Cyclin E associated events during G1/S transition
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin D associated events in G1
Cyclin E associated events during G1/S transition
Protein-Protein Interactions (177)
1 – 10 of 177
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.999999928
p_ni: 7.2e-8
Score: 0.981
Data Source: BioPlex,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.999999864
p_ni: 1.29e-7
p_wrong: 7e-9
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
CITED1
Tbio
Novelty: 0.01956689
p_int: 0.999998904
p_ni: 0.000001095
p_wrong: 1e-9
Data Source: BioPlex
CCND3
Tchem
Novelty: 0.00223085
p_int: 0.999995754
p_ni: 0.000004245
Score: 0.99
Data Source: BioPlex,STRINGDB
TXNDC11
Tbio
Novelty: 0.07135045
p_int: 0.999584796
p_ni: 0.000413816
p_wrong: 0.000001388
Score: 0.554
Data Source: BioPlex,STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
p_int: 0.999260351
p_ni: 0.000738918
p_wrong: 7.3e-7
Score: 0.967
Data Source: BioPlex,Reactome,STRINGDB
RARG
Tclin
Family: NR
Novelty: 0.00667159
p_int: 0.995769365
p_ni: 0.004129688
p_wrong: 0.000100946
Score: 0.241
Data Source: BioPlex,STRINGDB
CCND2
Tbio
Novelty: 0.00157305
p_int: 0.994564353
p_ni: 0.005419532
p_wrong: 0.000016114
Score: 0.992
Data Source: BioPlex,STRINGDB
E2F4
Tbio
Family: TF
Novelty: 0.00317412
Score: 0.997
Data Source: Reactome,STRINGDB
E2F5
Tbio
Family: TF
Novelty: 0.00674159
Score: 0.995
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  829.96

PubMed score by year
PubTator Score  307.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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