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Tbio
SSRP1
FACT complex subunit SSRP1

Protein Summary
Description
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional co ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278412
  • ENSP00000278412
  • ENSG00000149136

Symbol
  • FACT80
  • FACT
  • T160
  • FACT80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
disease perturbation
0.96
drug perturbation
0.96
kinase perturbation
0.96
co-expressed gene
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
4
91.9
pappalysin‐1 measurement
1
2
2
89.6
eosinophil percentage of leukocytes
2
3
3
80.7
mean corpuscular volume
1
1
1
53.3
high density lipoprotein cholesterol measurement
1
1
0
1.8
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
91.9
pappalysin‐1 measurement
2
89.6
eosinophil percentage of leukocytes
3
80.7
mean corpuscular volume
1
53.3
high density lipoprotein cholesterol measurement
0
1.8
39.6
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
structure specific recognition protein 1
VGNC:995
451188
Macaque
structure specific recognition protein 1
706614
Mouse
MGI:107912
20833
Rat
RGD:621143
81785
Dog
structure specific recognition protein 1
VGNC:46841
475970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
structure specific recognition protein 1
Macaque
structure specific recognition protein 1
Mouse
Rat
Dog
structure specific recognition protein 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q08945-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
Protein-Protein Interactions (286)
1 – 10 of 286
TONSL
Tbio
Novelty:  0.07220129
p_int:  0.999999052
p_ni:  9.48e-7
Score:  0.696
Data Source:  BioPlex,STRINGDB
MMS22L
Tbio
Novelty:  0.22570578
p_int:  0.999995817
p_ni:  0.000004182
Score:  0.777
Data Source:  BioPlex,STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.999989518
p_ni:  0.000010482
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999596599
p_ni:  0.000403401
Score:  0.893
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999449421
p_ni:  0.000550579
Score:  0.749
Data Source:  BioPlex,STRINGDB
XPC
Tbio
Novelty:  0.00775175
p_int:  0.997919678
p_ni:  0.002080322
Score:  0.725
Data Source:  BioPlex,STRINGDB
TIMELESS
Tbio
Novelty:  0.0041528
p_int:  0.997550629
p_ni:  0.002449371
Score:  0.735
Data Source:  BioPlex,STRINGDB
MACROD1
Tchem
Family:  Enzyme
Novelty:  0.03610474
p_int:  0.997337581
p_ni:  0.002662419
Score:  0.631
Data Source:  BioPlex,STRINGDB
MCM2
Tbio
Novelty:  0.00276275
p_int:  0.995231201
p_ni:  0.004768799
Score:  0.961
Data Source:  BioPlex,STRINGDB
MCM4
Tchem
Novelty:  0.00604311
p_int:  0.989938038
p_ni:  0.010061962
Score:  0.947
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  81.00

PubMed score by year
PubTator Score  66.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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