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Tclin
ITK
Tyrosine-protein kinase ITK/TSK

Protein Summary
Description
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ulti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000422843
  • ENSP00000398655
  • ENSG00000113263

Symbol
  • EMT
  • LYK
  • EMT
  • LYK
  • LPFS1
  • PSCTK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
hub protein
0.88
biological process
0.73
kinase
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1798.22   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 465   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1798.22   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 465   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 224
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
70.1
T-cell immunoglobulin and mucin domain 1 measurement
1
1
1
67.3
eosinophil count
1
1
1
20.5
Thyroid preparation use measurement
1
1
1
13.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
70.1
T-cell immunoglobulin and mucin domain 1 measurement
1
67.3
eosinophil count
1
20.5
Thyroid preparation use measurement
1
13.1
Protein Data Bank (36)
1 – 5 of 36
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (46)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
FCERI mediated Ca+2 mobilization
Reactome
Fc epsilon receptor (FCERI) signaling
Reactome
Generation of second messenger molecules
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
FCERI mediated Ca+2 mobilization
Fc epsilon receptor (FCERI) signaling
Generation of second messenger molecules
Immune System
Protein-Protein Interactions (186)
1 – 10 of 186
HSP90AB3P
Tdark
p_int: 0.999999133
p_ni: 8.67e-7
Data Source: BioPlex
HSP90AA5P
Tdark
p_int: 0.999847104
p_ni: 0.000152891
p_wrong: 6e-9
Data Source: BioPlex
DYNC1I2
Tbio
Novelty: 0.00228615
p_int: 0.999732299
p_ni: 0.000267701
Score: 0.34
Data Source: BioPlex,STRINGDB
HSP90AB1
Tchem
Novelty: 0.00907961
p_int: 0.896603641
p_ni: 0.103396359
Score: 0.323
Data Source: BioPlex,STRINGDB
GAPDHS
Tbio
Family: Enzyme
Novelty: 0.00885959
p_int: 0.885553277
p_ni: 0.114446722
p_wrong: 1e-9
Score: 0.243
Data Source: BioPlex,STRINGDB
CDC37
Tbio
Novelty: 0.03730196
p_int: 0.842517469
p_ni: 0.157482531
Score: 0.225
Data Source: BioPlex,STRINGDB
LCP2
Tbio
Novelty: 0.00512968
Score: 0.996
Data Source: Reactome,STRINGDB
CD3E
Tclin
Novelty: 0.0053855
Score: 0.99
Data Source: STRINGDB
CD247
Tbio
Novelty: 0.00217194
Score: 0.985
Data Source: STRINGDB
LAT
Tbio
Novelty: 0.00738419
Score: 0.981
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1798.22

PubMed score by year
PubTator Score  991.56

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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