You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
ADCY1
Adenylate cyclase type 1

Protein Summary
Description
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297323
  • ENSP00000297323
  • ENSG00000164742

Symbol
  • AC1
  • DFNB44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
molecular function
0.94
transcription factor perturbation
0.91
pathway
0.79
cell type or tissue
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.02   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.02   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (468)
P84996
Tbio
Novelty:  0.00284739
Score:  0.967
Data Source:  STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.967
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.967
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.967
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.958
Data Source:  STRINGDB
DRD1
Tclin
Family:  GPCR
Novelty:  0.00165886
Score:  0.957
Data Source:  STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
Score:  0.957
Data Source:  STRINGDB
DRD5
Tchem
Family:  GPCR
Novelty:  0.00803909
Score:  0.953
Data Source:  STRINGDB
DRD2
Tclin
Family:  GPCR
Novelty:  0.00033797
Score:  0.953
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets (33)
Explore Nearest Tclin Targets
Pathways (115)
Activation of GABAB receptors (R-HSA-991365)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of GABAB receptors
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Adenylate cyclase activating pathway
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Aquaporin-mediated transport
Name
Explore in Pharos
Explore in Source
Activation of GABAB receptors
Activation of NMDA receptors and postsynaptic events
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Aquaporin-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
3
3
90.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
3
90.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 1
VGNC:13624
463392
Macaque
adenylate cyclase 1
697230
Mouse
MGI:99677
432530
Rat
RGD:1309318
305509
Dog
adenylate cyclase 1
VGNC:37618
607357
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 1
Macaque
adenylate cyclase 1
Mouse
Rat
Dog
adenylate cyclase 1
Publication Statistics
PubMed Score 102.02
PubMed score by year
PubTator Score 174.36
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title