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Tchem
CD47
Leukocyte surface antigen CD47

Protein Summary
Description
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355354
  • ENSP00000347512
  • ENSG00000196776
  • ENST00000361309
  • ENSP00000355361

Symbol
  • MER6
  • IAP
  • OA3
  • MER6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
virus perturbation
0.99
biological term
0.88
kinase perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 925.01   (req: < 5)
Gene RIFs: 138   (req: <= 3)
Antibodies: 1158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 925.01   (req: >= 5)
Gene RIFs: 138   (req: > 3)
Antibodies: 1158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3946082
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
39.8
smoking behaviour measurement
1
1
1
35.8
mathematical ability
2
1
2
22.9
cognitive function measurement
1
1
1
18.7
1
1
0
1.1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
39.8
smoking behaviour measurement
1
35.8
mathematical ability
2
22.9
cognitive function measurement
1
18.7
0
1.1
11.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD47 molecule
VGNC:11369
460569
Macaque
CD47 molecule
704980
Mouse
MGI:96617
16423
Rat
RGD:2308
29364
Dog
CD47 molecule
VGNC:38960
478552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD47 molecule
Macaque
CD47 molecule
Mouse
Rat
Dog
CD47 molecule
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q08722-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Cell-Cell communication
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Cell-Cell communication
Extracellular matrix organization
Hemostasis
Immune System
Protein-Protein Interactions (265)
1 – 10 of 265
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.998057283
p_ni: 0.001942159
p_wrong: 5.58e-7
Data Source: BioPlex
LILRB4
Tbio
Novelty: 0.01443658
p_int: 0.998048797
p_ni: 0.001951135
p_wrong: 6.8e-8
Score: 0.205
Data Source: BioPlex,STRINGDB
TSPAN5
Tbio
Novelty: 0.08879443
p_int: 0.972383623
p_ni: 0.027616072
p_wrong: 3.05e-7
Score: 0.323
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.96765114
p_ni: 0.032347826
p_wrong: 0.000001033
Score: 0.195
Data Source: BioPlex,STRINGDB
LGALS9C
Tdark
Novelty: 0.29969898
p_int: 0.966006049
p_ni: 0.033834154
p_wrong: 0.000159798
Score: 0.524
Data Source: BioPlex,STRINGDB
BSCL2
Tbio
Novelty: 0.00483959
p_int: 0.952525962
p_ni: 0.046945616
p_wrong: 0.000528423
Score: 0.516
Data Source: BioPlex,STRINGDB
FZD4
Tchem
Family: GPCR
Novelty: 0.00577957
p_int: 0.94978833
p_ni: 0.047096797
p_wrong: 0.003114873
Data Source: BioPlex
S1PR1
Tclin
Family: GPCR
Novelty: 0.00162513
p_int: 0.947436568
p_ni: 0.05254979
p_wrong: 0.000013643
Data Source: BioPlex
KLRG2
Tdark
Novelty: 1.19446694
p_int: 0.942995464
p_ni: 0.05700394
p_wrong: 5.97e-7
Data Source: BioPlex
RETREG3
Tdark
Novelty: 0.99215801
p_int: 0.941508685
p_ni: 0.058491163
p_wrong: 1.52e-7
Score: 0.542
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  925.01

PubMed score by year
PubTator Score  399.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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