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Tbio
SPOCK1
Testican-1

Protein Summary
Description
May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system. This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394945
  • ENSP00000378401
  • ENSG00000152377

Symbol
  • SPOCK
  • TIC1
  • TICN1
  • TIC1
  • SPOCK
  • TESTICAN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
microRNA
0.94
PubMedID
0.86
kinase perturbation
0.84
transcription factor binding site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.94   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.94   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
3
3
84.7
mathematical ability
1
1
0
2.4
60.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
84.7
mathematical ability
0
2.4
60.3
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (38)
1 – 10 of 38
SPARC
Tbio
Novelty: 0.00063267
Score: 0.794
Data Source: STRINGDB
SPARCL1
Tbio
Novelty: 0.01077806
Score: 0.739
Data Source: STRINGDB
MMP16
Tchem
Family: Enzyme
Novelty: 0.01028533
Score: 0.671
Data Source: STRINGDB
CHD1L
Tbio
Family: Enzyme
Novelty: 0.00980287
Score: 0.655
Data Source: STRINGDB
STS
Tchem
Family: Enzyme
Novelty: 0.00324549
Score: 0.641
Data Source: STRINGDB
MMP14
Tchem
Family: Enzyme
Novelty: 0.00083836
Score: 0.587
Data Source: STRINGDB
CGREF1
Tbio
Novelty: 0.21713964
Score: 0.583
Data Source: STRINGDB
SERTM1
Tdark
Novelty: 2.95056388
Score: 0.557
Data Source: STRINGDB
SMOC1
Tbio
Novelty: 0.03819681
Score: 0.554
Data Source: STRINGDB
TG
Tbio
Novelty: 0.00010111
Score: 0.551
Data Source: STRINGDB
Publication Statistics
PubMed Score  91.94

PubMed score by year
PubTator Score  45.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer