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Tbio
PUDP
Pseudouridine-5'-phosphatase

Protein Summary
Description
Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine. This gene encodes a member of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The encoded protein has no known biological function. This gene has a pseudogene on chromosome 1. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381077
  • ENSP00000370467
  • ENSG00000130021
  • ENST00000412827
  • ENSP00000406260
  • ENST00000424830
  • ENSP00000396452
  • ENST00000540122
  • ENSP00000441208

Symbol
  • DXF68S1E
  • FAM16AX
  • GS1
  • HDHD1
  • HDHD1A
  • GS1
  • HDHD1
  • HDHD1A
  • FAM16AX
  • DXF68S1E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


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GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.66   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.66   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
dehydroepiandrosterone sulphate measurement
1
1
2
37.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
dehydroepiandrosterone sulphate measurement
2
37.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pseudouridine 5'-phosphatase
707930
Mouse
MGI:1914615
67365
Rat
RGD:1305101
291585
Dog
pseudouridine 5'-phosphatase
VGNC:45205
610678
Horse
pseudouridine 5'-phosphatase [Source:HGNC Symbol;Acc:HGNC:16818]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pseudouridine 5'-phosphatase
Mouse
Rat
Dog
pseudouridine 5'-phosphatase
Horse
pseudouridine 5'-phosphatase [Source:HGNC Symbol;Acc:HGNC:16818]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q08623-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Pyrimidine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Pyrimidine salvage
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (94)
1 – 10 of 94
PGM3
Tbio
Family: Enzyme
Novelty: 0.00515842
Score: 0.945
Data Source: STRINGDB
PNPLA4
Tbio
Family: Enzyme
Novelty: 0.07471752
Score: 0.882
Data Source: STRINGDB
ENOPH1
Tbio
Family: Enzyme
Novelty: 0.07679925
Score: 0.814
Data Source: STRINGDB
CFAP206
Tdark
Novelty: 1.22847252
Score: 0.79
Data Source: STRINGDB
UBE3D
Tbio
Family: Enzyme
Novelty: 0.44919491
Score: 0.783
Data Source: STRINGDB
RFK
Tbio
Family: Enzyme
Novelty: 0.00973729
Score: 0.769
Data Source: STRINGDB
CPPED1
Tbio
Family: Enzyme
Novelty: 0.10475831
Score: 0.745
Data Source: STRINGDB
PRSS35
Tbio
Family: Enzyme
Novelty: 0.28801395
Score: 0.738
Data Source: STRINGDB
DOP1A
Tdark
Novelty: 0.040097
Score: 0.725
Data Source: STRINGDB
VCX3A
Tbio
Novelty: 0.07353654
Score: 0.7
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.66

PubMed score by year
PubTator Score  69.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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