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Tbio
DSC1
Desmocollin-1

Protein Summary
Description
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257197
  • ENSP00000257197
  • ENSG00000134765
  • ENST00000257198
  • ENSP00000257198

Symbol
  • CDHF1
  • CDHF1
  • DG2/DG3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
interacting protein
0.78
cellular component
0.69
cell line
0.6
gene perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.82   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.82   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
PKP1
Tbio
Novelty:  0.0100609
Score:  0.992
Data Source:  STRINGDB
PKP3
Tbio
Novelty:  0.0269462
Score:  0.991
Data Source:  STRINGDB
DSP
Tbio
Novelty:  0.00178018
Score:  0.991
Data Source:  STRINGDB
PKP2
Tbio
Novelty:  0.00493803
Score:  0.989
Data Source:  STRINGDB
JUP
Tbio
Novelty:  0.0081803
Score:  0.986
Data Source:  STRINGDB
EVPL
Tbio
Novelty:  0.00274279
Score:  0.956
Data Source:  STRINGDB
KLK5
Tchem
Family:  Enzyme
Novelty:  0.00835407
Score:  0.956
Data Source:  STRINGDB
LOR
Tbio
Novelty:  0.0033781
Score:  0.954
Data Source:  STRINGDB
PKP4
Tbio
Novelty:  0.03654703
Score:  0.953
Data Source:  STRINGDB
PPL
Tbio
Novelty:  0.00684645
Score:  0.953
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Immune System
Innate Immune System
Keratinization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
desmocollin 1
VGNC:5155
455354
Macaque
desmocollin 1
705332
Mouse
MGI:109173
13505
Dog
desmocollin 1
VGNC:40100
490501
Horse
desmocollin 1
VGNC:17319
100065884
Species
Name
OMA
EggNOG
Inparanoid
Chimp
desmocollin 1
Macaque
desmocollin 1
Mouse
Dog
desmocollin 1
Horse
desmocollin 1
Publication Statistics
PubMed Score 61.82
PubMed score by year
PubTator Score 62.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title