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Tclin
PDE4D
cAMP-specific 3',5'-cyclic phosphodiesterase 4D

Protein Summary
Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309641
  • ENSP00000308485
  • ENSG00000113448
  • ENST00000317118
  • ENSP00000321739
  • ENST00000340635
  • ENSP00000345502
  • ENST00000358923
  • ENSP00000351800
  • ENST00000360047
  • ENSP00000353152
  • ENST00000405755
  • ENSP00000384806
  • ENST00000502484
  • ENSP00000423094
  • ENST00000502575
  • ENSP00000425917
  • ENST00000503258
  • ENSP00000425605
  • ENST00000507116
  • ENSP00000424852

Symbol
  • DPDE3
  • DPDE3
  • PDE43
  • STRK1
  • ACRDYS2
  • HSPDE4D
  • PDE4DN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
trait
1
molecular function
0.99
co-expressed gene
0.96
microRNA
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.7   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 427   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.7   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 427   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 439
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
7
7
96.7
Oral ulcer
1
1
0
1.1
96.6
cognitive function measurement
3
2
3
89.5
1
1
0
1.5
84.3
mathematical ability
1
2
2
82.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
7
96.7
Oral ulcer
0
1.1
96.6
cognitive function measurement
3
89.5
0
1.5
84.3
mathematical ability
2
82.2
Protein Structure (54 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q08499-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 54
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (41)
DARPP-32 events (R-HSA-180024)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DARPP-32 events
Reactome
G alpha (i) signalling events
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Opioid Signalling
Name
Explore in Pharos
Explore in Source
DARPP-32 events
G alpha (i) signalling events
G alpha (s) signalling events
GPCR downstream signalling
Opioid Signalling
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (164)
1 – 10 of 164
PDE4B
Tclin
Family: Enzyme
Novelty: 0.00528932
p_int: 0.999999595
p_wrong: 4.05e-7
Score: 0.856
Data Source: BioPlex,STRINGDB
AK3
Tbio
Family: Kinase
Novelty: 0.02673466
Score: 0.916
Data Source: STRINGDB
PDE4DIP
Tbio
Novelty: 0.03414104
Score: 0.913
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.912
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.905
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.904
Data Source: STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.903
Data Source: STRINGDB
ADCY9
Tbio
Family: Enzyme
Novelty: 0.00744116
Score: 0.878
Data Source: STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.874
Data Source: STRINGDB
ADCY7
Tbio
Family: Enzyme
Novelty: 0.00984562
Score: 0.834
Data Source: STRINGDB
Publication Statistics
PubMed Score  284.70

PubMed score by year
PubTator Score  229.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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