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Tchem
ADCY2
Adenylate cyclase type 2

Protein Summary
Description
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338316
  • ENSP00000342952
  • ENSG00000078295

Symbol
  • KIAA1060
  • AC2
  • HBAC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
biological process
0.95
disease perturbation
0.95
pathway
0.84
microRNA
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.41   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.41   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (16)
CHEMBL4751732
Rendered image for CHEMBL4751732
CHEMBL4750740
Rendered image for CHEMBL4750740
CHEMBL4740707
Rendered image for CHEMBL4740707
CHEMBL4777571
Rendered image for CHEMBL4777571
CHEMBL4761309
Rendered image for CHEMBL4761309
CHEMBL4762531
Rendered image for CHEMBL4762531
CHEMBL4744648
Rendered image for CHEMBL4744648
CHEMBL4758446
Rendered image for CHEMBL4758446
CHEMBL4764988
Rendered image for CHEMBL4764988
CHEMBL4784488
Rendered image for CHEMBL4784488
Protein-Protein Interactions (479)
GDE1
Tbio
Family:  Enzyme
Novelty:  0.05854843
p_int:  0.999157181
p_ni:  0.000440346
p_wrong:  0.000402473
Score:  0.174
Data Source:  BioPlex,STRINGDB
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.988876299
p_ni:  0.008494922
p_wrong:  0.002628779
Data Source:  BioPlex
ANKMY2
Tdark
Novelty:  0.50777631
p_int:  0.98792767
p_ni:  0.01207233
Data Source:  BioPlex
EMC7
Tdark
Novelty:  0.28771768
p_int:  0.933595103
p_ni:  0.066404886
p_wrong:  1.1e-8
Data Source:  BioPlex
EMC10
Tbio
Novelty:  0.04986528
p_int:  0.903465873
p_ni:  0.087575824
p_wrong:  0.008958303
Data Source:  BioPlex
SNX17
Tbio
Novelty:  0.03960737
p_int:  0.899787751
p_ni:  0.100156035
p_wrong:  0.000056214
Data Source:  BioPlex
EMC8
Tbio
Novelty:  0.2452967
p_int:  0.893731687
p_ni:  0.106179764
p_wrong:  0.000088549
Data Source:  BioPlex
EMC3
Tbio
Novelty:  0.01113829
p_int:  0.795857428
p_ni:  0.204142483
p_wrong:  8.8e-8
Data Source:  BioPlex
P63092
Tbio
Novelty:  0.00284739
Score:  0.978
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.978
Data Source:  STRINGDB
Nearest Tclin Targets (33)
Explore Nearest Tclin Targets
Pathways (120)
Activation of GABAB receptors (R-HSA-991365)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase activating pathway
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Aquaporin-mediated transport
Reactome
Ca-dependent events
Name
Explore in Pharos
Explore in Source
Activation of GABAB receptors
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Aquaporin-mediated transport
Ca-dependent events
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
coffee consumption measurement
3
2
3
78.3
3
3
1
1.1
70.1
wellbeing measurement
2
2
2
67.9
lifestyle measurement
1
1
1
67.8
mathematical ability
3
2
3
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
coffee consumption measurement
3
78.3
1
1.1
70.1
wellbeing measurement
2
67.9
lifestyle measurement
1
67.8
mathematical ability
3
66.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
adenylate cyclase 2
695328
Mouse
MGI:99676
210044
Rat
RGD:619965
81636
Dog
adenylate cyclase 2
VGNC:37619
478624
Horse
adenylate cyclase 2
VGNC:15087
100071337
Species
Name
OMA
EggNOG
Inparanoid
Macaque
adenylate cyclase 2
Mouse
Rat
Dog
adenylate cyclase 2
Horse
adenylate cyclase 2
Publication Statistics
PubMed Score 43.41
PubMed score by year
PubTator Score 155.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title