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Tbio
MFGE8
Lactadherin

Protein Summary
Description
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Medin is the main constituent of aortic medial amyloid. This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268150
  • ENSP00000268150
  • ENSG00000140545
  • ENST00000268151
  • ENSP00000268151
  • ENST00000542878
  • ENSP00000444332
  • ENST00000566497
  • ENSP00000456281

Symbol
  • BA46
  • HMFG
  • MFGM
  • SED1
  • hP47
  • EDIL1
  • MFG-E8
  • SPAG10
  • OAcGD3S
  • HsT19888
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.98
kinase perturbation
0.95
PubMedID
0.83
small molecule perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1002.91   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 633   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1002.91   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0