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Tbio
EHHADH
Peroxisomal bifunctional enzyme

Protein Summary
Description
The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231887
  • ENSP00000231887
  • ENSG00000113790
  • ENST00000456310
  • ENSP00000387746

Symbol
  • ECHD
  • LBP
  • ECHD
  • LBFP
  • PBFE
  • FRTS3
  • L-PBE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
interacting protein
0.97
gene perturbation
0.92
transcription factor perturbation
0.88
histone modification site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (170)
HSD17B4
Tbio
Novelty:  0.00547499
Score:  0.984
Data Source:  STRINGDB
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
Score:  0.982
Data Source:  STRINGDB
ACOX3
Tchem
Family:  Enzyme
Novelty:  0.04077258
Score:  0.982
Data Source:  STRINGDB
ACOX2
Tbio
Family:  Enzyme
Novelty:  0.02942359
Score:  0.981
Data Source:  STRINGDB
ACAA1
Tbio
Family:  Enzyme
Novelty:  0.00710465
Score:  0.981
Data Source:  STRINGDB
ACADM
Tbio
Family:  Enzyme
Novelty:  0.00548721
Score:  0.98
Data Source:  STRINGDB
ACOT4
Tbio
Family:  Enzyme
Novelty:  0.13441184
Score:  0.98
Data Source:  STRINGDB
PECR
Tbio
Family:  Enzyme
Novelty:  0.01550165
Score:  0.978
Data Source:  STRINGDB
ACAA2
Tbio
Family:  Enzyme
Novelty:  0.01452373
Score:  0.977
Data Source:  STRINGDB
HADHB
Tbio
Family:  Enzyme
Novelty:  0.00969194
Score:  0.976
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
Pathways (41)
Beta-oxidation of very long chain fatty acids (R-HSA-390247)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of very long chain fatty acids
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Name
Explore in Pharos
Explore in Source
Beta-oxidation of very long chain fatty acids
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
2
2
40.1
1
1
0
1.2
30.6
educational attainment
1
1
1
18.4
self reported educational attainment
1
1
1
12.1
mathematical ability
1
1
1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
40.1
0
1.2
30.6
educational attainment
1
18.4
self reported educational attainment
1
12.1
mathematical ability
1
2.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
VGNC:14238
460996
Macaque
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
701193
Mouse
MGI:1277964
74147
Rat
RGD:621441
171142
Dog
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
VGNC:40250
488110
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Macaque
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Mouse
Rat
Dog
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Publication Statistics
PubMed Score 125.55
PubMed score by year
PubTator Score 83.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title