EHHADH
Peroxisomal bifunctional enzyme
Protein Summary
The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
- ENST00000231887
- ENSP00000231887
- ENSG00000113790
- ENST00000456310
- ENSP00000387746
- ECHD
- LBP
- ECHD
- LBFP
- PBFE
- FRTS3
- L-PBE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
interacting protein | 0.97 | ||
gene perturbation | 0.92 | ||
transcription factor perturbation | 0.88 | ||
histone modification site profile | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 125.55 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 297 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 125.55 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 297 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0