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Tbio
GOLGA3
Golgin subfamily A member 3

Protein Summary
Description
Golgi auto-antigen; probably involved in maintaining Golgi structure. The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000204726
  • ENSP00000204726
  • ENSG00000090615
  • ENST00000450791
  • ENSP00000410378
  • ENST00000456883
  • ENSP00000409303
  • ENST00000545875
  • ENSP00000442603

Symbol
  • MEA-2
  • GCP170
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
cellular component
0.81
kinase perturbation
0.81
histone modification site profile
0.77
gene perturbation
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.43   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.43   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
82.4
smoking status measurement
2
1
2
80.1
visceral adipose tissue measurement
1
1
1
62.4
body mass index
1
1
1
60
1
1
0
1.2
30.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
82.4
smoking status measurement
2
80.1
visceral adipose tissue measurement
1
62.4
body mass index
1
60
0
1.2
30.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgin A3
VGNC:5403
467167
Macaque
golgin A3
694167
Mouse
MGI:96958
269682
Rat
RGD:1305262
312077
Dog
golgin A3
VGNC:41339
477435
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgin A3
Macaque
golgin A3
Mouse
Rat
Dog
golgin A3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q08378-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (65)
1 – 10 of 65
SYCE1
Tbio
Novelty: 0.05038876
p_int: 0.999993784
p_ni: 0.000006216
Data Source: BioPlex
SYNC
Tbio
Novelty: 0.04605223
p_int: 0.999904088
p_ni: 0.000095912
Data Source: BioPlex
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
p_int: 0.999895046
p_ni: 0.000104954
Data Source: BioPlex
DEUP1
Tbio
Novelty: 0.13274391
p_int: 0.999806958
p_ni: 0.000193042
Score: 0.186
Data Source: BioPlex,STRINGDB
TSNAX
Tbio
Novelty: 0.00888891
p_int: 0.99928223
p_ni: 0.00071777
Score: 0.811
Data Source: BioPlex,STRINGDB
GOPC
Tbio
Novelty: 0.01110168
p_int: 0.998082368
p_ni: 0.001917632
Score: 0.723
Data Source: BioPlex,STRINGDB
BFSP1
Tbio
Novelty: 0.01519136
p_int: 0.997521422
p_ni: 0.002478578
Data Source: BioPlex
WASHC3
Tdark
Novelty: 0.18307321
p_int: 0.955540115
p_ni: 0.044459885
Data Source: BioPlex
LRRC36
Tdark
Novelty: 2.03789632
p_int: 0.952144089
p_ni: 0.047855911
Score: 0.188
Data Source: BioPlex,STRINGDB
FUOM
Tbio
Family: Enzyme
Novelty: 0.0562349
p_int: 0.919678342
p_ni: 0.080321658
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  31.43

PubMed score by year
PubTator Score  23.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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