Tbio SLC20A2 Sodium-dependent phosphate transporter 2

Protein Summary

Description

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• Q08357

Gene Name

• SLC20A2

Ensembl ID

• ENST00000342228
• ENSP00000340465
• ENSG00000168575
• ENST00000520179
• ENSP00000429712
• ENST00000520262
• ENSP00000429754

Symbol

• GLVR2
• PIT2
• PIT2
• RAM1
• GLVR2
• IBGC1
• IBGC3
• MLVAR
• PIT-2
• Ram-1
• GLVR-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.85
transcription factor binding site profile	0.85
molecular function	0.84
virus perturbation	0.79
disease perturbation	0.74

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc20 Family Of Sodium-dependent Phosphate Transporters / Sodium-dependent Phosphate Transporter 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.7   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 144   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.7   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0