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Tchem
DDR1
Epithelial discoidin domain-containing receptor 1

Protein Summary
Description
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259875
  • ENSP00000259875
  • ENSG00000137332
  • ENST00000324771
  • ENSP00000318217
  • ENSG00000204580
  • ENST00000376567
  • ENSP00000365751
  • ENST00000376568
  • ENSP00000365752
  • ENST00000376569
  • ENSP00000365753
  • ENST00000376570
  • ENSP00000365754
  • ENST00000376575
  • ENSP00000365759
  • ENST00000383377
  • ENSP00000372868
  • ENST00000400410
  • ENSP00000383261
  • ENST00000400411
  • ENSP00000383262
  • ENST00000400414
  • ENSP00000383265
  • ENST00000400486
  • ENSP00000383334
  • ENSG00000215522
  • ENST00000400488
  • ENSP00000383336
  • ENST00000400489
  • ENSP00000383337
  • ENST00000400491
  • ENSP00000383338
  • ENST00000400492
  • ENSP00000383339
  • ENST00000412329
  • ENSP00000391805
  • ENSG00000230456
  • ENST00000415092
  • ENSP00000405540
  • ENST00000418800
  • ENSP00000407699
  • ENST00000419412
  • ENSP00000416183
  • ENSG00000234078
  • ENST00000421229
  • ENSP00000415730
  • ENST00000427053
  • ENSP00000416145
  • ENST00000429699
  • ENSP00000401397
  • ENST00000430933
  • ENSP00000397769
  • ENST00000449518
  • ENSP00000414285
  • ENST00000452441
  • ENSP00000405039
  • ENST00000453510
  • ENSP00000401208
  • ENST00000454612
  • ENSP00000406091
  • ENST00000454774
  • ENSP00000400393
  • ENST00000482873
  • ENSP00000421978
  • ENST00000508312
  • ENSP00000422442
  • ENST00000513240
  • ENSP00000427552
  • ENST00000548133
  • ENSP00000449611
  • ENST00000548962
  • ENSP00000448115
  • ENST00000549026
  • ENSP00000449238
  • ENST00000550384
  • ENSP00000447474
  • ENST00000550395
  • ENSP00000449255
  • ENST00000552068
  • ENSP00000449190
  • ENST00000552721
  • ENSP00000449307
  • ENST00000553015
  • ENSP00000448377
  • ENST00000617572
  • ENSP00000479195
  • ENST00000618059
  • ENSP00000479204
  • ENST00000620318
  • ENSP00000484588
  • ENST00000621544
  • ENSP00000484013

Symbol
  • CAK
  • EDDR1
  • NEP
  • NTRK4
  • PTK3A
  • RTK6
  • TRKE
  • CAK
  • DDR
  • NEP
  • HGK2
  • PTK3
  • RTK6
  • TRKE
  • CD167
  • EDDR1
  • MCK10
  • NTRK4
  • PTK3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.99
transcription factor perturbation
0.96
disease perturbation
0.93
PubMedID
0.93


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.07   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 706   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.07   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 706   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (35)
Items per page:
1 – 5 of 35
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
8.6
92.4
1
1
0
8.6
92.4
1
1
0
8.6
92.4
1
1
0
8.6
92.4
1
1
0
8.6
92.4
Items per page:
1 – 5 of 35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
8.6
92.4
0
8.6
92.4
0
8.6
92.4
0
8.6
92.4
0
8.6
92.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
discoidin domain receptor tyrosine kinase 1
VGNC:12633
462548
Macaque
discoidin domain receptor tyrosine kinase 1
714233
Mouse
MGI:99216
12305
Dog
discoidin domain receptor tyrosine kinase 1
100856512
Horse
discoidin domain receptor tyrosine kinase 1
100050861
Species
Name
OMA
EggNOG
Inparanoid
Chimp
discoidin domain receptor tyrosine kinase 1
Macaque
discoidin domain receptor tyrosine kinase 1
Mouse
Dog
discoidin domain receptor tyrosine kinase 1
Horse
discoidin domain receptor tyrosine kinase 1
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q08345-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Non-integrin membrane-ECM interactions
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Non-integrin membrane-ECM interactions
Gene Ontology Terms (35)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (39)
1 – 10 of 39
EVA1B
Tdark
Novelty: 2.1380272
p_int: 0.996244793
p_ni: 0.003699583
p_wrong: 0.000055624
Data Source: BioPlex
TNFRSF10B
Tbio
Novelty: 0.00054433
p_int: 0.965955183
p_ni: 0.000506309
p_wrong: 0.033538509
Score: 0.226
Data Source: BioPlex,STRINGDB
TM4SF1
Tbio
Novelty: 0.02410436
Score: 0.693
Data Source: STRINGDB
COL3A1
Tbio
Novelty: 0.00197327
Score: 0.692
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.67
Data Source: STRINGDB
ITGA2
Tbio
Novelty: 0.0013482
Score: 0.653
Data Source: STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
Score: 0.619
Data Source: STRINGDB
COL4A1
Tbio
Novelty: 0.00358049
Score: 0.59
Data Source: STRINGDB
CYSTM1
Tdark
Novelty: 1.37759108
Score: 0.559
Data Source: STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.552
Data Source: STRINGDB
Publication Statistics
PubMed Score  276.07

PubMed score by year
PubTator Score  168.72

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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