Tbio IL10RB Interleukin-10 receptor subunit beta

Protein Summary

Description

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q08334
• Q9BUU4
• IL-10 receptor subunit beta

Gene Name

• IL10RB

Ensembl ID

• ENST00000290200
• ENSP00000290200
• ENSG00000243646

Symbol

• CRFB4
• D21S58
• D21S66
• CRFB4
• CRF2-4
• D21S58
• D21S66
• CDW210B
• IL-10R2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
transcription factor perturbation	0.91
PubMedID	0.88
histone modification site profile	0.81
gene perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interleukin-10 Receptor Subunit Beta

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-10 Receptor Subunit Beta

Protein / Defense/immunity Protein / Interleukin-10 Receptor Subunit Beta

DTO Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interleukin-10 Receptor Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.65   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 316   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.65   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0