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Tbio
IL10RB
Interleukin-10 receptor subunit beta

Protein Summary
Description
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290200
  • ENSP00000290200
  • ENSG00000243646

Symbol
  • CRFB4
  • D21S58
  • D21S66
  • CRFB4
  • CRF2-4
  • D21S58
  • D21S66
  • CDW210B
  • IL-10R2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor perturbation
0.91
PubMedID
0.88
histone modification site profile
0.81
gene perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.66   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.66   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin-10 receptor B measurement
1
1
1
61.8
1
1
0
1.3
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin-10 receptor B measurement
1
61.8
0
1.3
4
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Interleukin-20 family signaling
Reactome
Other interleukin signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Interleukin-20 family signaling
Other interleukin signaling
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (109)
1 – 10 of 109
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.967759576
p_ni: 1.1e-7
p_wrong: 0.032240313
Score: 0.265
Data Source: BioPlex,STRINGDB
IFNLR1
Tbio
Novelty: 0.01990628
Score: 0.996
Data Source: Reactome,STRINGDB
IFNL3
Tbio
Novelty: 0.00069262
Score: 0.995
Data Source: Reactome,STRINGDB
IL10RA
Tbio
Novelty: 0.00506068
Score: 0.995
Data Source: Reactome,STRINGDB
IL22RA1
Tbio
Novelty: 0.01107638
Score: 0.989
Data Source: Reactome,STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.981
Data Source: Reactome,STRINGDB
IFNL2
Tbio
Novelty: 0.01468568
Score: 0.981
Data Source: Reactome,STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.981
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.979
Data Source: Reactome,STRINGDB
IL22
Tbio
Novelty: 0.0023754
Score: 0.977
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  86.66

PubMed score by year
PubTator Score  69.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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