CACNB2
Voltage-dependent L-type calcium channel subunit beta-2
Protein Summary
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]
- ENST00000282343
- ENSP00000282343
- ENSG00000165995
- ENST00000324631
- ENSP00000320025
- ENST00000352115
- ENSP00000344474
- ENST00000377315
- ENSP00000366532
- ENST00000377319
- ENSP00000366536
- ENST00000377329
- ENSP00000366546
- ENST00000396576
- ENSP00000379821
- ENST00000645287
- ENSP00000496203
- CACNLB2
- MYSB
- MYSB
- CAVB2
- CACNLB2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.99 | ||
kinase perturbation | 0.95 | ||
molecular function | 0.84 | ||
transcription factor | 0.82 | ||
PubMedID | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.97 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 548 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.97 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 548 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0