Tbio CRYZ Quinone oxidoreductase

Protein Summary

Description

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• Q08257
• A6NN60
• D3DQ76
• Q53FT0
• Q59EU7
• Q5HYE7
• Q6NSK9

Gene Name

• CRYZ

Ensembl ID

• ENST00000340866
• ENSP00000339399
• ENSG00000116791
• ENST00000370871
• ENSP00000359908
• ENST00000370872
• ENSP00000359909
• ENST00000417775
• ENSP00000399805

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
histone modification site profile	0.9
protein domain	0.85
kinase perturbation	0.84
transcription factor binding site profile	0.75

Protein Classes

DTO Classes

Electron Transfer Flavoprotein-ubiquinone Oxidoreductase, Mitochondrial / Nadh-ubiquinone Oxidoreductase Chain 1 / Nadh-ubiquinone Oxidoreductase Chain 5 / Quinone Oxidoreductase Pig3 / Nadh-ubiquinone Oxidoreductase Chain 4 / Nadh-ubiquinone Oxidoreductase 75 Kda Subunit, Mitochondrial / Nadh-ubiquinone Oxidoreductase Chain 4l

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.62   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.62   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0