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Tbio
CRYZ
Quinone oxidoreductase

Protein Summary
Description
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340866
  • ENSP00000339399
  • ENSG00000116791
  • ENST00000370871
  • ENSP00000359908
  • ENST00000370872
  • ENSP00000359909
  • ENST00000417775
  • ENSP00000399805
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
histone modification site profile
0.9
protein domain
0.85
kinase perturbation
0.84
transcription factor binding site profile
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 505.05   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 505.05   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
53.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
53.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin zeta
VGNC:10592
456952
Macaque
glutamate rich 3 [Source:HGNC Symbol;Acc:HGNC:25346]
Mouse
MGI:88527
12972
Rat
RGD:1311639
362061
Dog
crystallin zeta
611431
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin zeta
Macaque
glutamate rich 3 [Source:HGNC Symbol;Acc:HGNC:25346]
Mouse
Rat
Dog
crystallin zeta
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q08257-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (120)
1 – 10 of 120
MTG2
Tbio
Family: Enzyme
Novelty: 0.06104792
p_int: 0.99918147
p_ni: 0.000810818
p_wrong: 0.000007712
Data Source: BioPlex
TRIP13
Tbio
Family: Enzyme
Novelty: 0.00660506
p_int: 0.977668623
p_ni: 0.022331377
Score: 0.544
Data Source: BioPlex,STRINGDB
MUT
Tbio
Family: Enzyme
Novelty: 0.00074807
p_int: 0.944545592
p_ni: 0.055454408
Score: 0.198
Data Source: BioPlex,STRINGDB
PREPL
Tchem
Family: Enzyme
Novelty: 0.02310586
p_int: 0.839984927
p_ni: 0.160015072
p_wrong: 1e-9
Data Source: BioPlex
GLS
Tchem
Family: Enzyme
Novelty: 0.00321692
p_int: 0.82617392
p_ni: 0.173623636
p_wrong: 0.000202444
Score: 0.202
Data Source: BioPlex,STRINGDB
MTIF2
Tbio
Novelty: 0.06681774
p_int: 0.822388196
p_ni: 0.177611796
p_wrong: 8e-9
Score: 0.213
Data Source: BioPlex,STRINGDB
NFE2L2
Tchem
Family: TF
Novelty: 0.00043828
Score: 0.982
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.937
Data Source: STRINGDB
NQO1
Tchem
Family: Enzyme
Novelty: 0.00055755
Score: 0.929
Data Source: STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00006103
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  505.05

PubMed score by year
PubTator Score  100.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer