Tchem TGM3 Protein-glutamine gamma-glutamyltransferase E

Protein Summary

Description

Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q08188
• A8K5N6
• B2RCR6
• D3DVX1
• O95933
• Q32ML9
• Q32MM0

Gene Name

• TGM3

Ensembl ID

• ENST00000381458
• ENSP00000370867
• ENSG00000125780

Symbol

• TGE
• UHS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
interacting protein	0.71
gene perturbation	0.7
PubMedID	0.68
tissue sample	0.62

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Protein-glutamine Gamma-glutamyltransferase E

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Protein-glutamine Gamma-glutamyltransferase E

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.33   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 296   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.33   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0