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Tbio
SRSF4
Serine/arginine-rich splicing factor 4

Protein Summary
Description
Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373795
  • ENSP00000362900
  • ENSG00000116350

Symbol
  • SFRS4
  • SRP75
  • SFRS4
  • SRP75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.9
transcription factor binding site profile
0.9
ligand (protein) perturbation
0.83
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.26   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.26   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
65
hemoglobin measurement
2
1
2
62.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
65
hemoglobin measurement
2
62.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 4
VGNC:9518
740597
Macaque
serine and arginine rich splicing factor 4
717401
Mouse
MGI:1890577
57317
Rat
RGD:1561347
362612
Dog
serine and arginine rich splicing factor 4
VGNC:46820
478160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 4
Macaque
serine and arginine rich splicing factor 4
Mouse
Rat
Dog
serine and arginine rich splicing factor 4
Pathways (13)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (280)
1 – 10 of 280
RNPS1
Tbio
Novelty: 0.03203224
Score: 0.986
Data Source: STRINGDB
SRRM1
Tbio
Novelty: 0.03770186
Score: 0.981
Data Source: STRINGDB
SRRM2
Tbio
Novelty: 0.03914644
Score: 0.981
Data Source: STRINGDB
SF3A2
Tbio
Novelty: 0.03658692
Score: 0.977
Data Source: STRINGDB
TRA2B
Tbio
Novelty: 0.0146833
Score: 0.977
Data Source: STRINGDB
SNRNP70
Tbio
Novelty: 0.00116631
Score: 0.976
Data Source: STRINGDB
SRSF2
Tbio
Novelty: 0.00207072
Score: 0.974
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.974
Data Source: STRINGDB
U2AF2
Tbio
Novelty: 0.00590935
Score: 0.973
Data Source: STRINGDB
SRSF11
Tbio
Novelty: 0.17035604
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.26

PubMed score by year
PubTator Score  17.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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