Tbio AES Amino-terminal enhancer of split

Protein Summary

Description

Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q08117
• B2RBL0
• Q12808
• Q14CJ1
• Q96TG9
• Q9UDY9
• Amino enhancer of split

Gene Name

• AES

Ensembl ID

• ENST00000221561
• ENSP00000221561
• ENSG00000104964
• ENST00000327141
• ENSP00000317537

Symbol

• GRG
• GRG5
• AES
• GRG
• ESP1
• GRG5
• AES-1
• AES-2
• Grg-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
virus perturbation	0.85
biological process	0.82
PubMedID	0.73
tissue	0.62

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Amino-terminal Enhancer Of Split

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Amino-terminal Enhancer Of Split

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.51   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 365   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.51   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0