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Tbio
AES
Amino-terminal enhancer of split

Protein Summary
Description
Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221561
  • ENSP00000221561
  • ENSG00000104964
  • ENST00000327141
  • ENSP00000317537

Symbol
  • GRG
  • GRG5
  • AES
  • GRG
  • ESP1
  • GRG5
  • AES-1
  • AES-2
  • Grg-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
virus perturbation
0.85
biological process
0.82
PubMedID
0.73
tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.78   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.78   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
96.3
monocyte percentage of leukocytes
1
1
1
10.7
mean platelet volume
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
96.3
monocyte percentage of leukocytes
1
10.7
mean platelet volume
1
1.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amino-terminal enhancer of split
744806
Mouse
MGI:95806
14797
Rat
RGD:2731
29466
Cow
amino-terminal enhancer of split
505375
Opossum
amino-terminal enhancer of split
100009729
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amino-terminal enhancer of split
Mouse
Rat
Cow
amino-terminal enhancer of split
Opossum
amino-terminal enhancer of split
Pathways (12)
Degradation of beta-catenin by the destruction complex (R-HSA-195253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of beta-catenin by the destruction complex
Reactome
Repression of WNT target genes
Reactome
Signal Transduction
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Degradation of beta-catenin by the destruction complex
Repression of WNT target genes
Signal Transduction
Signaling by WNT
Protein-Protein Interactions (67)
1 – 10 of 67
TLE4
Tbio
Novelty: 0.02094922
p_int: 1
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
TLE1
Tbio
Novelty: 0.00594261
p_int: 0.999999998
p_ni: 2e-9
Score: 0.947
Data Source: BioPlex,Reactome,STRINGDB
MFAP4
Tbio
Novelty: 0.02023782
p_int: 0.999999925
p_ni: 7.5e-8
Data Source: BioPlex
RIPPLY2
Tdark
Novelty: 0.16163153
p_int: 0.999999839
p_ni: 1.61e-7
Score: 0.694
Data Source: BioPlex,STRINGDB
TLE2
Tbio
Novelty: 0.03922169
p_int: 0.999998861
p_ni: 0.000001139
Score: 0.908
Data Source: BioPlex,Reactome,STRINGDB
RIPPLY1
Tdark
Novelty: 0.11705603
p_int: 0.999850986
p_ni: 0.000147421
p_wrong: 0.000001593
Score: 0.831
Data Source: BioPlex,STRINGDB
HLX
Tbio
Family: TF
Novelty: 0.00982861
p_int: 0.999035328
p_ni: 0.000964668
p_wrong: 4e-9
Score: 0.753
Data Source: BioPlex,STRINGDB
VENTX
Tbio
Family: TF
Novelty: 0.09005259
p_int: 0.998204709
p_ni: 0.00175632
p_wrong: 0.000038971
Score: 0.875
Data Source: BioPlex,STRINGDB
STARD7
Tbio
Novelty: 0.04511594
p_int: 0.970700654
p_ni: 0.00291266
p_wrong: 0.026386686
Score: 0.187
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  126.78

PubMed score by year
PubTator Score  53.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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