Protein Summary
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele. The non-functional allele of this gene is associated with elite athlete status. [provided by RefSeq, Feb 2014]
- ENST00000513398
- ENSP00000426797
- ENSG00000248746
- ACTN3D
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.92 | ||
interacting protein | 0.83 | ||
biological term | 0.78 | ||
PubMedID | 0.77 | ||
molecular function | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.03 (req: < 5)
Gene RIFs: 147 (req: <= 3)
Antibodies: 224 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.03 (req: >= 5)
Gene RIFs: 147 (req: > 3)
Antibodies: 224 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (162)
AKAP17A
Family: Enzyme
Novelty: 0.02860381
p_int: 0.999998985
p_ni: 0.000001015
Score: 0.187
Data Source: BioPlex,STRINGDB
MECOM
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.999998782
p_ni: 0.000001164
p_wrong: 5.4e-8
Data Source: BioPlex
LZTR1
Novelty: 0.02363333
p_int: 0.999990931
p_ni: 0.000009054
p_wrong: 1.5e-8
Data Source: BioPlex
LRRCC1
Novelty: 0.14730953
p_int: 0.999989826
p_ni: 0.000009728
p_wrong: 4.46e-7
Score: 0.224
Data Source: BioPlex,STRINGDB
TMEM183A
Novelty: 0.4017284
p_int: 0.99997705
p_ni: 0.00002067
p_wrong: 0.00000228
Data Source: BioPlex
BCHE
Family: Enzyme
Novelty: 0.00031267
p_int: 0.999969882
p_ni: 0.000030112
p_wrong: 6e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (13)
Reactome (4)
KEGG (1)
PathwayCommons (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell-Cell communication | ||||
Reactome | Muscle contraction | ||||
Reactome | Nephrin family interactions | ||||
Reactome | Striated Muscle Contraction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell-Cell communication | ||||
Muscle contraction | ||||
Nephrin family interactions | ||||
Striated Muscle Contraction | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (6)
Components (6)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 3 | 3 | 3 | 70 | |||||
apolipoprotein B measurement | 2 | 2 | 2 | 65.7 | |||||
insomnia measurement | 1 | 1 | 0 | 1 | 44.2 | ||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 28.1 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 3 | 70 | |||||
apolipoprotein B measurement | 2 | 65.7 | |||||
insomnia measurement | 0 | 1 | 44.2 | ||||
BMI-adjusted hip circumference | 1 | 28.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | actinin alpha 3 | 713811 | ||||||
Mouse | MGI:99678 | 11474 | ||||||
Rat | RGD:621792 | 171009 | ||||||
Dog | actinin alpha 3 | 483707 | ||||||
Horse | actinin alpha 3 | 100033871 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | actinin alpha 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | actinin alpha 3 | |||||
Horse | actinin alpha 3 | |||||
Publication Statistics
PubMed Score 285.03
PubMed score by year
PubTator Score 185.09
PubTator score by year
Related Publications
Text Mined References (187)
GeneRif Annotations (147)
Items per page:
0 of 0
PMID | Year | Title |
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