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Tbio
ACTN3
Alpha-actinin-3

Protein Summary
Description
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele. The non-functional allele of this gene is associated with elite athlete status. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000513398
  • ENSP00000426797
  • ENSG00000248746

Symbol
  • ACTN3D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
interacting protein
0.83
biological term
0.78
PubMedID
0.77
molecular function
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.74   (req: < 5)
View Publications
Gene RIFs: 147   (req: <= 3)
View Gene RIFs
Antibodies: 224   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.74   (req: >= 5)
Gene RIFs: 147   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
actinin alpha 3
713811
Mouse
actinin alpha 3
MGI:99678
11474
Rat
actinin alpha 3
RGD:621792
171009
Dog
actinin alpha 3
483707
Horse
actinin alpha 3
100033871
Species
Name
OMA
EggNOG
Inparanoid
Macaque
actinin alpha 3
Mouse
actinin alpha 3
Rat
actinin alpha 3
Dog
actinin alpha 3
Horse
actinin alpha 3
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Cell-Cell communication (R-HSA-1500931)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell-Cell communication
121 targets
R-HSA-1500931
Reactome
Muscle contraction
202 targets
R-HSA-397014
Reactome
Nephrin family interactions
21 targets
R-HSA-373753
Reactome
Striated Muscle Contraction
34 targets
R-HSA-390522
Name
Explore in Pharos
Explore in Source
Cell-Cell communication
121 targets
R-HSA-1500931
Muscle contraction
202 targets
R-HSA-397014
Nephrin family interactions
21 targets
R-HSA-373753
Striated Muscle Contraction
34 targets
R-HSA-390522
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
ion channel binding
Inferred from Physical Interaction (IPI)
UniProtKB
integrin binding
Traceable Author Statement (TAS)
UniProtKB
protein homodimerization activity
Traceable Author Statement (TAS)
UniProtKB
structural constituent of muscle
Traceable Author Statement (TAS)
ProtInc
actin binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
calcium ion binding
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (162)
1 – 10 of 162
PDLIM1
Tbio
Novelty: 0.02703639
p_int: 1
Score: 0.596
Data Source: BioPlex,STRINGDB
RSPH6A
Tdark
Novelty: 0.03734897
p_int: 0.99999998
p_ni: 1.9e-8
p_wrong: 1e-9
Data Source: BioPlex
AKAP17A
Tbio
Family: Enzyme
Novelty: 0.02860381
p_int: 0.999998985
p_ni: 0.000001015
Score: 0.187
Data Source: BioPlex,STRINGDB
MECOM
Tbio
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.999998782
p_ni: 0.000001164
p_wrong: 5.4e-8
Data Source: BioPlex
LZTR1
Tbio
Novelty: 0.02363333
p_int: 0.999990931
p_ni: 0.000009054
p_wrong: 1.5e-8
Data Source: BioPlex
LRRCC1
Tdark
Novelty: 0.14730953
p_int: 0.999989826
p_ni: 0.000009728
p_wrong: 4.46e-7
Score: 0.224
Data Source: BioPlex,STRINGDB
TMEM183A
Tdark
Novelty: 0.4017284
p_int: 0.99997705
p_ni: 0.00002067
p_wrong: 0.00000228
Data Source: BioPlex
BCHE
Tclin
Family: Enzyme
Novelty: 0.00031267
p_int: 0.999969882
p_ni: 0.000030112
p_wrong: 6e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
VCL
Tbio
Novelty: 0.00043107
Score: 0.99
Data Source: STRINGDB
ACTN4
Tbio
Novelty: 0.0040236
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  276.74

PubMed score by year
PubTator Score  185.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer