Protein Summary
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele. The non-functional allele of this gene is associated with elite athlete status. [provided by RefSeq, Feb 2014]
- ENST00000513398
- ENSP00000426797
- ENSG00000248746
- ACTN3D
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
interacting protein | 0.83 | ||
biological term | 0.78 | ||
PubMedID | 0.77 | ||
molecular function | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.03 (req: < 5)
Gene RIFs: 147 (req: <= 3)
Antibodies: 224 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.03 (req: >= 5)
Gene RIFs: 147 (req: > 3)
Antibodies: 224 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (162)
AKAP17A
Family: Enzyme
Novelty: 0.02860381
p_int: 0.999998985
p_ni: 0.000001015
Score: 0.187
Data Source: BioPlex,STRINGDB
MECOM
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.999998782
p_ni: 0.000001164
p_wrong: 5.4e-8
Data Source: BioPlex
LZTR1
Novelty: 0.02363333
p_int: 0.999990931
p_ni: 0.000009054
p_wrong: 1.5e-8
Data Source: BioPlex
LRRCC1
Novelty: 0.14730953
p_int: 0.999989826
p_ni: 0.000009728
p_wrong: 4.46e-7
Score: 0.224
Data Source: BioPlex,STRINGDB
TMEM183A
Novelty: 0.4017284
p_int: 0.99997705
p_ni: 0.00002067
p_wrong: 0.00000228
Data Source: BioPlex
BCHE
Family: Enzyme
Novelty: 0.00031267
p_int: 0.999969882
p_ni: 0.000030112
p_wrong: 6e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (13)
Reactome (4)
KEGG (1)
PathwayCommons (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell-Cell communication | ||||
Reactome | Muscle contraction | ||||
Reactome | Nephrin family interactions | ||||
Reactome | Striated Muscle Contraction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell-Cell communication | ||||
Muscle contraction | ||||
Nephrin family interactions | ||||
Striated Muscle Contraction | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (6)
Components (6)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 3 | 3 | 3 | 70 | |||||
apolipoprotein B measurement | 2 | 2 | 2 | 65.7 | |||||
insomnia measurement | 1 | 1 | 0 | 1 | 44.2 | ||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 28.1 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 3 | 70 | |||||
apolipoprotein B measurement | 2 | 65.7 | |||||
insomnia measurement | 0 | 1 | 44.2 | ||||
BMI-adjusted hip circumference | 1 | 28.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | actinin alpha 3 | 713811 | ||||||
Mouse | MGI:99678 | 11474 | ||||||
Rat | RGD:621792 | 171009 | ||||||
Dog | actinin alpha 3 | 483707 | ||||||
Horse | actinin alpha 3 | 100033871 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | actinin alpha 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | actinin alpha 3 | |||||
Horse | actinin alpha 3 | |||||
Publication Statistics
PubMed Score 285.03
PubMed score by year
PubTator Score 185.09
PubTator score by year
Related Publications
Text Mined References (187)
GeneRif Annotations (147)
Items per page:
0 of 0
PMID | Year | Title |
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