Tbio ARHGAP1 Rho GTPase-activating protein 1

Protein Summary

Description

GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate. This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q07960
• D3DQQ6

Gene Name

• ARHGAP1

Ensembl ID

• ENST00000311956
• ENSP00000310491
• ENSG00000175220

Symbol

• CDC42GAP
• RHOGAP1
• RHOGAP
• RHOGAP1
• CDC42GAP
• p50rhoGAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
transcription factor perturbation	0.91
transcription factor binding site profile	0.86
histone modification site profile	0.81
kinase perturbation	0.76

Protein Classes

DTO Classes

Rho Gtpase-activating Protein 15 / Rho Gtpase-activating Protein 12 / Rho Gtpase-activating Protein 19 / Rho Gtpase-activating Protein 10 / Slit-robo Rho Gtpase-activating Protein 1 / Rho Gtpase-activating Protein 18

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.2   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 211   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.2   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0