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Tbio
LRP1
Prolow-density lipoprotein receptor-related protein 1

Protein Summary
Description
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438). (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in sever ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243077
  • ENSP00000243077
  • ENSG00000123384
  • ENST00000338962
  • ENSP00000341264

Symbol
  • A2MR
  • APR
  • APR
  • KPA
  • LRP
  • A2MR
  • CD91
  • APOER
  • LRP1A
  • TGFBR5
  • IGFBP3R
  • IGFBP-3R
  • IGFBP3R1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.87
hub protein
0.85
molecular function
0.84
biological term
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 530.05   (req: < 5)
Gene RIFs: 259   (req: <= 3)
Antibodies: 959   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 530.05   (req: >= 5)
Gene RIFs: 259   (req: > 3)
Antibodies: 959   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1
0
1.1
97.4
Headache
1
1
1
85.9
2
2
0
1.1
82.2
2
1
0
1.2
78.9
spontaneous coronary artery dissection
1
1
0
1.7
77.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97.4
Headache
1
85.9
0
1.1
82.2
0
1.2
78.9
spontaneous coronary artery dissection
0
1.7
77.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LDL receptor related protein 1
VGNC:5459
452006
Macaque
LDL receptor related protein 1
710965
Mouse
MGI:96828
16971
Rat
RGD:1307535
299858
Dog
LDL receptor related protein 1
VGNC:42771
481124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LDL receptor related protein 1
Macaque
LDL receptor related protein 1
Mouse
Rat
Dog
LDL receptor related protein 1
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Metabolism of fat-soluble vitamins
Gene Ontology Terms (66)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Protein-Protein Interactions (207)
1 – 10 of 207
KCTD18
Tdark
Novelty: 0.8176728
p_int: 0.999921441
p_ni: 1.16e-7
p_wrong: 0.000078443
Score: 0.237
Data Source: BioPlex,STRINGDB
INTS6
Tbio
Novelty: 0.02680242
p_int: 0.99962092
p_ni: 0.00037908
Score: 0.162
Data Source: BioPlex,STRINGDB
TNKS2
Tchem
Family: Enzyme
Novelty: 0.00938509
p_int: 0.999207475
p_ni: 0.000792525
Score: 0.202
Data Source: BioPlex,STRINGDB
TNKS
Tchem
Family: Enzyme
Novelty: 0.00404545
p_int: 0.999137156
p_ni: 0.000862844
Score: 0.204
Data Source: BioPlex,STRINGDB
FOXF2
Tbio
Family: TF
Novelty: 0.02032168
p_int: 0.999009362
p_ni: 0.000874924
p_wrong: 0.000115714
Score: 0.153
Data Source: BioPlex,STRINGDB
ANKRD36B
Tdark
Novelty: 2.44907149
p_int: 0.998425696
p_ni: 0.001574303
Data Source: BioPlex
BCKDHB
Tbio
Family: Enzyme
Novelty: 0.02234969
p_int: 0.997880965
p_ni: 0.00211893
p_wrong: 1.06e-7
Data Source: BioPlex
TUBB8
Tclin
Novelty: 0.06403117
p_int: 0.991870456
p_ni: 0.008129544
Data Source: BioPlex
SAMD1
Tdark
Novelty: 0.21956379
p_int: 0.991421431
p_ni: 0.008578509
p_wrong: 6.1e-8
Data Source: BioPlex
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.991263675
p_ni: 0.008736325
Data Source: BioPlex
Publication Statistics
PubMed Score  530.05

PubMed score by year
PubTator Score  924.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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