Tbio LRP1 Prolow-density lipoprotein receptor-related protein 1

Protein Summary

Description

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438). (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• Q07954
• Q2PP12
• Q86SW0
• Q8IVG8
• LRP-1

Gene Name

• LRP1

Ensembl ID

• ENST00000243077
• ENSP00000243077
• ENSG00000123384
• ENST00000338962
• ENSP00000341264

Symbol

• A2MR
• APR
• APR
• KPA
• LRP
• A2MR
• CD91
• APOER
• LRP1A
• TGFBR5
• IGFBP3R
• IGFBP-3R
• IGFBP3R1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
biological process	0.87
hub protein	0.85
molecular function	0.84
biological term	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 604.37   (req: < 5)

Gene RIFs: 324   (req: <= 3)

Antibodies: 959   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 604.37   (req: >= 5)

Gene RIFs: 324   (req: > 3)

Antibodies: 959   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0