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Tclin
TNK2
Activated CDC42 kinase 1

Protein Summary
Description
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333602
  • ENSP00000329425
  • ENSG00000061938
  • ENST00000381916
  • ENSP00000371341
  • ENST00000439230
  • ENSP00000395588

Symbol
  • ACK1
  • ACK
  • ACK1
  • ACK-1
  • p21cdc42Hs
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
transcription factor perturbation
0.88
hub protein
0.85
interacting protein
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.39   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 713   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.39   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 713   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 118
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3