Protein Summary
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosph ...more
- ENST00000333602
- ENSP00000329425
- ENSG00000061938
- ENST00000381916
- ENSP00000371341
- ENST00000439230
- ENSP00000395588
- ACK1
- ACK
- ACK1
- ACK-1
- p21cdc42Hs
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
protein domain | 1 | ||
transcription factor perturbation | 0.88 | ||
hub protein | 0.85 | ||
interacting protein | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 127.31 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 713 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 127.31 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 713 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 116
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (116)
Protein-Protein Interactions (98)
NCK1
Novelty: 0.00352084
p_int: 0.999999964
p_ni: 3.4e-8
p_wrong: 1e-9
Score: 0.658
Data Source: BioPlex,STRINGDB
NCK2
Novelty: 0.02220251
p_int: 0.999999663
p_ni: 1.17e-7
p_wrong: 2.21e-7
Score: 0.428
Data Source: BioPlex,STRINGDB
ISG15
Novelty: 0.00203781
p_int: 0.999975164
p_ni: 0.00000885
p_wrong: 0.000015986
Score: 0.274
Data Source: BioPlex,STRINGDB
GRB2
Novelty: 0.00091605
p_int: 0.983686966
p_ni: 7.95e-7
p_wrong: 0.016312239
Score: 0.924
Data Source: BioPlex,STRINGDB
CDC37
Novelty: 0.03730196
p_int: 0.786919817
p_ni: 0.213080183
Score: 0.358
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
PathwayCommons (2)
WikiPathways (4)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: netpath | EGFR1 | ||||
PathwayCommons: pid | CDC42 signaling events | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
EGFR1 | ||||
CDC42 signaling events | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (11)
Components (12)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
creatinine measurement | 1 | 1 | 1 | 48.5 | |||||
glomerular filtration rate | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
creatinine measurement | 1 | 48.5 | |||||
glomerular filtration rate | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | tyrosine kinase non receptor 2 | 711655 | ||||||
Mouse | MGI:1858308 | 51789 | ||||||
Rat | RGD:1305957 | 303882 | ||||||
Dog | tyrosine kinase non receptor 2 | VGNC:47680 | 488025 | |||||
Horse | tyrosine kinase non receptor 2 [Source:HGNC Symbol;Acc:HGNC:19297] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | tyrosine kinase non receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tyrosine kinase non receptor 2 | |||||
Horse | tyrosine kinase non receptor 2 [Source:HGNC Symbol;Acc:HGNC:19297] | |||||
Publication Statistics
PubMed Score 127.31
PubMed score by year
PubTator Score 109.34
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (88)
GeneRif Annotations (55)
Items per page:
0 of 0
PMID | Year | Title |
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