You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
TNK2
Activated CDC42 kinase 1

Protein Summary
Description
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333602
  • ENSP00000329425
  • ENSG00000061938
  • ENST00000381916
  • ENSP00000371341
  • ENST00000439230
  • ENSP00000395588

Symbol
  • ACK1
  • ACK
  • ACK1
  • ACK-1
  • p21cdc42Hs
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
transcription factor perturbation
0.88
hub protein
0.85
interacting protein
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.66   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 713   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.66   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 713   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 69
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (32)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (98)
1 – 10 of 98
NCK1
Tbio
Novelty: 0.00352084
p_int: 0.999999964
p_ni: 3.4e-8
p_wrong: 1e-9
Score: 0.658
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999999663
p_ni: 1.17e-7
p_wrong: 2.21e-7
Score: 0.428
Data Source: BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int: 0.999989975
p_ni: 0.000010024
p_wrong: 1e-9
Data Source: BioPlex
ISG15
Tbio
Novelty: 0.00203781
p_int: 0.999975164
p_ni: 0.00000885
p_wrong: 0.000015986
Score: 0.274
Data Source: BioPlex,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
p_int: 0.983686966
p_ni: 7.95e-7
p_wrong: 0.016312239
Score: 0.924
Data Source: BioPlex,STRINGDB
CDC37
Tbio
Novelty: 0.03730196
p_int: 0.786919817
p_ni: 0.213080183
Score: 0.358
Data Source: BioPlex,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.998
Data Source: STRINGDB
BCAR1
Tbio
Novelty: 0.00329214
Score: 0.973
Data Source: STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.858
Data Source: STRINGDB
WWOX
Tbio
Family: Enzyme
Novelty: 0.00335243
Score: 0.849
Data Source: STRINGDB
Publication Statistics
PubMed Score  125.66

PubMed score by year
PubTator Score  109.34

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer