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Tbio
SOS2
Son of sevenless homolog 2

Protein Summary
Description
Promotes the exchange of Ras-bound GDP by GTP. This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216373
  • ENSP00000216373
  • ENSG00000100485
  • ENST00000543680
  • ENSP00000445328

Symbol
  • NS9
  • SOS-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.86
pathway
0.76
hub protein
0.75
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.82   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.82   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
95.9
testosterone measurement
2
1
2
82.9
intraocular pressure measurement
4
2
4
79.4
Agents acting on the renin-angiotensin system use measurement
1
1
1
32.2
birth weight
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
95.9
testosterone measurement
2
82.9
intraocular pressure measurement
4
79.4
Agents acting on the renin-angiotensin system use measurement
1
32.2
birth weight
1
29
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SOS Ras/Rho guanine nucleotide exchange factor 2
VGNC:8216
452897
Macaque
SOS Ras/Rho guanine nucleotide exchange factor 2
705601
Mouse
MGI:98355
20663
Rat
RGD:620435
85384
Dog
SOS Ras/Rho guanine nucleotide exchange factor 2
VGNC:46666
490682
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SOS Ras/Rho guanine nucleotide exchange factor 2
Macaque
SOS Ras/Rho guanine nucleotide exchange factor 2
Mouse
Rat
Dog
SOS Ras/Rho guanine nucleotide exchange factor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q07890-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (165)
Activation of RAC1 (R-HSA-428540)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAC1
Reactome
Axon guidance
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Cytokine Signaling in Immune system
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Activation of RAC1
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Cytokine Signaling in Immune system
Death Receptor Signalling
Protein-Protein Interactions (117)
1 – 10 of 117
GRB2
Tchem
Novelty: 0.00091605
p_int: 1
Score: 0.997
Data Source: BioPlex,STRINGDB
NCK1
Tbio
Novelty: 0.00352084
p_int: 0.999999975
p_ni: 7e-9
p_wrong: 1.8e-8
Score: 0.923
Data Source: BioPlex,Reactome,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.991
Data Source: STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
Score: 0.967
Data Source: STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.966
Data Source: STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.966
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.949
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.947
Data Source: Reactome,STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.947
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  54.82

PubMed score by year
PubTator Score  27.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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