Tbio SOS2 Son of sevenless homolog 2

Protein Summary

Description

Promotes the exchange of Ras-bound GDP by GTP. This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q07890
• B7ZKT6
• D3DSB4
• Q15503
• Q17RN1
• SOS-2

Gene Name

• SOS2

Ensembl ID

• ENST00000216373
• ENSP00000216373
• ENSG00000100485
• ENST00000543680
• ENSP00000445328

Symbol

• NS9
• SOS-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
histone modification site profile	0.86
pathway	0.76
hub protein	0.75
virus perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Son Of Sevenless Homolog 2

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Son Of Sevenless Homolog 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.62   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.62   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0