Tchem SOS1 Son of sevenless homolog 1

Protein Summary

Description

Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q07889
• A8K2G3
• B4DXG2
• SOS-1

Gene Name

• SOS1

Ensembl ID

• ENST00000402219
• ENSP00000384675
• ENSG00000115904
• ENST00000426016
• ENSP00000387784

Symbol

• GF1
• HGF
• NS4
• GGF1
• GINGF
• SOS-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	1
hub protein	0.99
protein domain	0.99
transcription factor binding site profile	0.91
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Son Of Sevenless Homolog 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Son Of Sevenless Homolog 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.17   (req: < 5)

Gene RIFs: 103   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.17   (req: >= 5)

Gene RIFs: 103   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 253

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0