PPARA
Peroxisome proliferator-activated receptor alpha
Protein Classes
Protein Summary
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid meta ...more
- ENST00000262735
- ENSP00000262735
- ENSG00000186951
- ENST00000402126
- ENSP00000385246
- ENST00000407236
- ENSP00000385523
- NR1C1
- PPAR
- PPAR
- NR1C1
- hPPAR
- PPARalpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
molecular function | 1 | ||
virus perturbation | 0.97 | ||
disease | 0.94 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6240.64 (req: < 5)
Gene RIFs: 406 (req: <= 3)
Antibodies: 706 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6240.64 (req: >= 5)
Gene RIFs: 406 (req: > 3)
Antibodies: 706 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 69
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 355
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 12
Approved Drugs (12)
1 – 10 of 12
Active Ligands (355)
1 – 10 of 355
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 3 | 2 | 3 | 96.8 | |||||
eosinophil count | 2 | 1 | 2 | 75.7 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 43.8 | |||||
triglyceride measurement | 1 | 1 | 1 | 37.7 | |||||
behavioural disinhibition measurement | 1 | 1 | 1 | 22 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
testosterone measurement | 3 | 96.8 | |||||
eosinophil count | 2 | 75.7 | |||||
eosinophil percentage of leukocytes | 1 | 43.8 | |||||
triglyceride measurement | 1 | 37.7 | |||||
behavioural disinhibition measurement | 1 | 22 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | peroxisome proliferator activated receptor alpha | VGNC:12916 | 458910 | |||||
Macaque | peroxisome proliferator activated receptor alpha | 613250 | ||||||
Mouse | MGI:104740 | 19013 | ||||||
Rat | RGD:3369 | 25747 | ||||||
Dog | peroxisome proliferator activated receptor alpha | VGNC:44834 | 403654 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | peroxisome proliferator activated receptor alpha | |||||
Macaque | peroxisome proliferator activated receptor alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | peroxisome proliferator activated receptor alpha | |||||
Protein Structure (18 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 18
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (47)
Reactome (24)
KEGG (7)
PathwayCommons (1)
WikiPathways (15)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 24
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
Reactome | Circadian Clock | ||||
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
Circadian Clock | ||||
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Gene Ontology Terms (72)
Functions (27)
Components (3)
Processes (42)
Items per page:
10
1 – 10 of 27
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Protein-Protein Interactions (282)
1 – 10 of 282
PPARGC1A
Novelty: 0.0003625
Score: 0.994
Data Source: STRINGDB
NCOA1
Family: Epigenetic
Novelty: 0.00344663
Score: 0.993
Data Source: STRINGDB
NCOR2
Family: TF
Novelty: 0.00066449
Score: 0.993
Data Source: STRINGDB
FABP1
Novelty: 0.00192691
Score: 0.988
Data Source: Reactome,STRINGDB
NCOR1
Family: TF
Novelty: 0.0021926
Score: 0.983
Data Source: STRINGDB
ACADM
Family: Enzyme
Novelty: 0.00548721
Score: 0.979
Data Source: STRINGDB
DUT
Family: Enzyme
Novelty: 0.0026993
Score: 0.978
Data Source: STRINGDB
ACOX1
Family: Enzyme
Novelty: 0.00473427
Score: 0.977
Data Source: STRINGDB
CPT1A
Family: Enzyme
Novelty: 0.00281783
Score: 0.974
Data Source: STRINGDB
HMGCS2
Family: Enzyme
Novelty: 0.0103808
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score 6240.64
PubMed score by year
PubTator Score 3419.56
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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