Tclin PPARA Peroxisome proliferator-activated receptor alpha

Protein Summary

Description

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q07869
• B0G0X3
• Q16241
• Q6I9S0
• Q92486
• Q92689
• Q9Y3N1
• PPAR-alpha

Gene Name

• PPARA

Ensembl ID

• ENST00000262735
• ENSP00000262735
• ENSG00000186951
• ENST00000402126
• ENSP00000385246
• ENST00000407236
• ENSP00000385523

Symbol

• NR1C1
• PPAR
• PPAR
• NR1C1
• hPPAR
• PPARalpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
molecular function	1
virus perturbation	0.97
disease	0.94

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Peroxisome Proliferator-activated Receptor Alpha

Protein / Receptor / Peroxisome Proliferator-activated Receptor Alpha

Protein / Nucleic Acid Binding / Peroxisome Proliferator-activated Receptor Alpha

Protein / ... / C4 Zinc Finger Nuclear Receptor / Peroxisome Proliferator-activated Receptor Alpha

DTO Classes

Protein / Nuclear Receptor / Peroxisome Proliferator-activated Receptors / Peroxisome Proliferator-activated Receptor Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6945.74   (req: < 5)

Gene RIFs: 471   (req: <= 3)

Antibodies: 706   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6945.74   (req: >= 5)

Gene RIFs: 471   (req: > 3)

Antibodies: 706   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 752

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12