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Tclin
PPARA
Peroxisome proliferator-activated receptor alpha

Protein Classes
Protein Summary
Description
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid meta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262735
  • ENSP00000262735
  • ENSG00000186951
  • ENST00000402126
  • ENSP00000385246
  • ENST00000407236
  • ENSP00000385523

Symbol
  • NR1C1
  • PPAR
  • PPAR
  • NR1C1
  • hPPAR
  • PPARalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
molecular function
1
virus perturbation
0.97
disease
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6240.64   (req: < 5)
Gene RIFs: 406   (req: <= 3)
Antibodies: 706   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6240.64   (req: >= 5)
Gene RIFs: 406   (req: > 3)
Antibodies: 706   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 355
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
2
3
96.8
eosinophil count
2
1
2
75.7
eosinophil percentage of leukocytes
1
1
1
43.8
triglyceride measurement
1
1
1
37.7
behavioural disinhibition measurement
1
1
1
22
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
96.8
eosinophil count
2
75.7
eosinophil percentage of leukocytes
1
43.8
triglyceride measurement
1
37.7
behavioural disinhibition measurement
1
22
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisome proliferator activated receptor alpha
VGNC:12916
458910
Macaque
peroxisome proliferator activated receptor alpha
613250
Mouse
MGI:104740
19013
Rat
RGD:3369
25747
Dog
peroxisome proliferator activated receptor alpha
VGNC:44834
403654
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisome proliferator activated receptor alpha
Macaque
peroxisome proliferator activated receptor alpha
Mouse
Rat
Dog
peroxisome proliferator activated receptor alpha
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q07869-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (47)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Developmental Biology
Gene expression (Transcription)
Gene Ontology Terms (72)
Items per page:
10
1 – 10 of 27
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (282)
1 – 10 of 282
PPARGC1A
Tbio
Novelty: 0.0003625
Score: 0.994
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.993
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.993
Data Source: STRINGDB
FABP1
Tchem
Novelty: 0.00192691
Score: 0.988
Data Source: Reactome,STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.983
Data Source: STRINGDB
ACADM
Tbio
Family: Enzyme
Novelty: 0.00548721
Score: 0.979
Data Source: STRINGDB
DUT
Tchem
Family: Enzyme
Novelty: 0.0026993
Score: 0.978
Data Source: STRINGDB
ACOX1
Tbio
Family: Enzyme
Novelty: 0.00473427
Score: 0.977
Data Source: STRINGDB
CPT1A
Tchem
Family: Enzyme
Novelty: 0.00281783
Score: 0.974
Data Source: STRINGDB
HMGCS2
Tbio
Family: Enzyme
Novelty: 0.0103808
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  6240.64

PubMed score by year
PubTator Score  3419.56

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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