PPARA
Peroxisome proliferator-activated receptor alpha
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
molecular function | 1 | ||
virus perturbation | 0.97 | ||
disease | 0.94 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
Reactome | Circadian Clock | ||||
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
Circadian Clock | ||||
Developmental Biology | ||||
Gene expression (Transcription) | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 3 | 3 | 6 | 89.8 | |||||
Dupuytren Contracture | 1 | 1 | 0 | 1.3 | 79.9 | ||||
body height | 1 | 1 | 1 | 78.9 | |||||
triglyceride measurement | 3 | 3 | 3 | 74.6 | |||||
eosinophil count | 2 | 1 | 2 | 74.4 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
testosterone measurement | 6 | 89.8 | |||||
Dupuytren Contracture | 0 | 1.3 | 79.9 | ||||
body height | 1 | 78.9 | |||||
triglyceride measurement | 3 | 74.6 | |||||
eosinophil count | 2 | 74.4 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | peroxisome proliferator activated receptor alpha | VGNC:12916 | 458910 | |||||
Macaque | peroxisome proliferator activated receptor alpha | 613250 | ||||||
Mouse | MGI:104740 | 19013 | ||||||
Rat | RGD:3369 | 25747 | ||||||
Dog | peroxisome proliferator activated receptor alpha | VGNC:44834 | 403654 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | peroxisome proliferator activated receptor alpha | |||||
Macaque | peroxisome proliferator activated receptor alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | peroxisome proliferator activated receptor alpha | |||||
PMID | Year | Title |
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