Tbio KLC1 Kinesin light chain 1

Protein Summary

Description

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q07866
• A6NF62
• F8VTM4
• Q7RTM2
• Q7RTM3
• Q7RTM5
• Q7RTP9
• Q7RTQ3
• Q7RTQ5
• Q7RTQ6
• Q86SF5
• Q86TF5
• Q86V74
• Q86V75
• Q86V76
• Q86V77
• Q86V78
• Q86V79
• Q96H62
• KLC 1

Gene Name

• KLC1

Ensembl ID

• ENST00000246489
• ENSP00000246489
• ENSG00000126214
• ENST00000334553
• ENSP00000334523
• ENST00000347839
• ENSP00000334618
• ENST00000348520
• ENSP00000341154
• ENST00000389744
• ENSP00000374394
• ENST00000452929
• ENSP00000414982
• ENST00000553286
• ENSP00000452487
• ENST00000554228
• ENSP00000450616
• ENST00000557450
• ENSP00000450648
• ENST00000634686
• ENSP00000488938

Symbol

• KLC
• KNS2
• KLC
• KNS2
• KNS2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	1
protein domain	0.97
virus perturbation	0.88
kinase perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.1   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 244   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.1   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0