Tbio KLC1 Kinesin light chain 1

Protein Summary

Description

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q07866
• A6NF62
• F8VTM4
• Q7RTM2
• Q7RTM3
• Q7RTM5
• Q7RTP9
• Q7RTQ3
• Q7RTQ5
• Q7RTQ6
• Q86SF5
• Q86TF5
• Q86V74
• Q86V75
• Q86V76
• Q86V77
• Q86V78
• Q86V79
• Q96H62
• KLC 1

Gene Name

• KLC1

Ensembl ID

• ENST00000246489
• ENSP00000246489
• ENSG00000126214
• ENST00000334553
• ENSP00000334523
• ENST00000347839
• ENSP00000334618
• ENST00000348520
• ENSP00000341154
• ENST00000389744
• ENSP00000374394
• ENST00000452929
• ENSP00000414982
• ENST00000553286
• ENSP00000452487
• ENST00000554228
• ENSP00000450616
• ENST00000557450
• ENSP00000450648
• ENST00000634686
• ENSP00000488938

Symbol

• KLC
• KNS2
• KLC
• KNS2
• KNS2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	1
protein domain	0.97
virus perturbation	0.88
kinase perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.7   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 244   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.7   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (205)

Explore Interacting Targets

1 – 10 of 205

• See Interactions on String-DB

KLC3

Tbio

Novelty:  0.0528937

p_int:  0.999999921

p_ni:  7.8e-8

p_wrong:  2e-9

Score:  0.982

Data Source:  BioPlex,STRINGDB

KIF5A

Tbio

Novelty:  0.01277095

p_int:  0.999999846

p_ni:  1.53e-7

p_wrong:  1e-9

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

KLC2

Tbio

Novelty:  0.06284367

p_int:  0.99999939

p_ni:  6.1e-7

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

SYNE4

Tbio

Novelty:  0.0739848

p_int:  0.999999272

p_ni:  7.28e-7

Score:  0.687

Data Source:  BioPlex,STRINGDB

KLC4

Tdark

Novelty:  0.32552746

p_int:  0.99999901

p_ni:  9.9e-7

Score:  0.993

Data Source:  BioPlex,STRINGDB

KIF5C

Tbio

Novelty:  0.0238573

p_int:  0.999996424

p_ni:  0.000003576

Score:  0.971

Data Source:  BioPlex,STRINGDB

TRIP6

Tbio

Novelty:  0.02183202

p_int:  0.999978151

p_ni:  0.000021849

Score:  0.562

Data Source:  BioPlex,STRINGDB

KIF5B

Tbio

Novelty:  0.00515256

p_int:  0.999972789

p_ni:  0.000027211

Score:  0.998

Data Source:  BioPlex,STRINGDB

COG6

Tbio

Novelty:  0.02874093

p_int:  0.99895974

p_ni:  0.001040259

Score:  0.441

Data Source:  BioPlex,STRINGDB

KIF2B

Tbio

Novelty:  0.09958244

p_int:  0.998770767

p_ni:  0.001229233

Score:  0.916

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (18)

Reactome (15)

KEGG (1)

PathwayCommons (2)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Golgi-to-ER retrograde transport	117 targets	R-HSA-8856688
Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Golgi-to-ER retrograde transport	117 targets	R-HSA-8856688
Hemostasis	666 targets	R-HSA-109582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (3)

Components (7)

Processes (7)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
motor activity	Traceable Author Statement (TAS)	ProtInc
microtubule motor activity	Inferred from Electronic Annotation (IEA)	InterPro
tubulin binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (32)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 32

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	1	3	3		91.6
reticulocyte count	EFO_0007986	4	3	4		91.4
intelligence	EFO_0004337	7	9	3	6	82.3
schizophrenia	EFO_0000692	10	8	4	1.1	80.5
serum gamma-glutamyl transferase measurement	EFO_0004532	1	1	1		77.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 32

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3		91.6
reticulocyte count	EFO_0007986	4		91.4
intelligence	EFO_0004337	3	6	82.3
schizophrenia	EFO_0000692	4	1.1	80.5
serum gamma-glutamyl transferase measurement	EFO_0004532	1		77.3

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Host-virus interaction
Microtubule

GWAS Trait Find Similar Targets

No Header	No Header
amino acid measurement
anorexia nervosa
attention deficit hyperactivity disorder
autism spectrum disorder
bipolar disorder
body height
body mass index
cigarettes per day measurement
cognitive function measurement
depressive symptom measurement

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	kinesin light chain 1	VGNC:12840	453188
Macaque	kinesin light chain 1		695677
Mouse	kinesin light chain 1	MGI:107978	16593
Rat	kinesin light chain 1	RGD:621411	171041
Dog	kinesin light chain 1		100855591

Species	Name	OMA	EggNOG	Inparanoid
Chimp	kinesin light chain 1
Macaque	kinesin light chain 1
Mouse	kinesin light chain 1
Rat	kinesin light chain 1
Dog	kinesin light chain 1

Publication Statistics

PubMed Score 89.70

PubMed score by year

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PubTator Score 37.62

PubTator score by year

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Related Publications

GeneRif Annotations (25)

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PMID	Text