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Tbio
KLC1
Kinesin light chain 1

Protein Summary
Description
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246489
  • ENSP00000246489
  • ENSG00000126214
  • ENST00000334553
  • ENSP00000334523
  • ENST00000347839
  • ENSP00000334618
  • ENST00000348520
  • ENSP00000341154
  • ENST00000389744
  • ENSP00000374394
  • ENST00000452929
  • ENSP00000414982
  • ENST00000553286
  • ENSP00000452487
  • ENST00000554228
  • ENSP00000450616
  • ENST00000557450
  • ENSP00000450648
  • ENST00000634686
  • ENSP00000488938

Symbol
  • KLC
  • KNS2
  • KLC
  • KNS2
  • KNS2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
protein domain
0.97
virus perturbation
0.88
kinase perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.7   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.7   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
3
3
91.6
reticulocyte count
4
3
4
91.4
intelligence
7
9
3
6
82.3
10
8
4
1.1
80.5
serum gamma-glutamyl transferase measurement
1
1
1
77.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
91.6
reticulocyte count
4
91.4
intelligence
3
6
82.3
4
1.1
80.5
serum gamma-glutamyl transferase measurement
1
77.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin light chain 1
VGNC:12840
453188
Macaque
kinesin light chain 1
695677
Mouse
MGI:107978
16593
Rat
RGD:621411
171041
Dog
kinesin light chain 1
100855591
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin light chain 1
Macaque
kinesin light chain 1
Mouse
Rat
Dog
kinesin light chain 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q07866-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (205)
1 – 10 of 205
KLC3
Tbio
Novelty:  0.0528937
p_int:  0.999999921
p_ni:  7.8e-8
p_wrong:  2e-9
Score:  0.982
Data Source:  BioPlex,STRINGDB
KIF5A
Tbio
Novelty:  0.01277095
p_int:  0.999999846
p_ni:  1.53e-7
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
KLC2
Tbio
Novelty:  0.06284367
p_int:  0.99999939
p_ni:  6.1e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.999999272
p_ni:  7.28e-7
Score:  0.687
Data Source:  BioPlex,STRINGDB
KLC4
Tdark
Novelty:  0.32552746
p_int:  0.99999901
p_ni:  9.9e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
KIF5C
Tbio
Novelty:  0.0238573
p_int:  0.999996424
p_ni:  0.000003576
Score:  0.971
Data Source:  BioPlex,STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.999978151
p_ni:  0.000021849
Score:  0.562
Data Source:  BioPlex,STRINGDB
KIF5B
Tbio
Novelty:  0.00515256
p_int:  0.999972789
p_ni:  0.000027211
Score:  0.998
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.99895974
p_ni:  0.001040259
Score:  0.441
Data Source:  BioPlex,STRINGDB
KIF2B
Tbio
Novelty:  0.09958244
p_int:  0.998770767
p_ni:  0.001229233
Score:  0.916
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  89.70

PubMed score by year
PubTator Score  37.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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