Tclin POLE DNA polymerase epsilon catalytic subunit A

Protein Summary

Description

Participates in DNA repair and in chromosomal DNA replication. This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q07864
• Q13533
• Q86VH9

Gene Name

• POLE

Ensembl ID

• ENST00000320574
• ENSP00000322570
• ENSG00000177084

Symbol

• POLE1
• FILS
• POLE1
• CRCS12
• IMAGEI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.88
protein domain	0.85
molecular function	0.84
cellular component	0.71
histone modification site profile	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 441.76   (req: < 5)

Gene RIFs: 128   (req: <= 3)

Antibodies: 160   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 441.76   (req: >= 5)

Gene RIFs: 128   (req: > 3)

Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2