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Tbio
SLC3A1
Neutral and basic amino acid transport protein rBAT

Protein Summary
Description
Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule. This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260649
  • ENSP00000260649
  • ENSG00000138079
  • ENST00000409229
  • ENSP00000386620
  • ENST00000409380
  • ENSP00000386709
  • ENST00000409740
  • ENSP00000386677
  • ENST00000409741
  • ENSP00000386954
  • ENST00000410056
  • ENSP00000387337

Symbol
  • RBAT
  • D2H
  • ATR1
  • NBAT
  • RBAT
  • CSNU1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
molecular function
0.81
cellular component
0.75
protein domain
0.73
small molecule perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.14   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.14   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0