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Tbio
SLC3A1
Neutral and basic amino acid transport protein rBAT

Protein Summary
Description
Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule. This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260649
  • ENSP00000260649
  • ENSG00000138079
  • ENST00000409229
  • ENSP00000386620
  • ENST00000409380
  • ENSP00000386709
  • ENST00000409740
  • ENSP00000386677
  • ENST00000409741
  • ENSP00000386954
  • ENST00000410056
  • ENSP00000387337

Symbol
  • RBAT
  • D2H
  • ATR1
  • NBAT
  • RBAT
  • CSNU1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
molecular function
0.81
cellular component
0.75
protein domain
0.73
small molecule perturbation
0.71


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.85   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.85   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
68.6
chronotype measurement
1
1
1
64.9
anxiety disorder measurement
2
2
3
50.5
daytime rest measurement
1
1
1
46.9
self reported educational attainment
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
68.6
chronotype measurement
1
64.9
anxiety disorder measurement
3
50.5
daytime rest measurement
1
46.9
self reported educational attainment
1
21.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 3 member 1
VGNC:10764
459194
Macaque
solute carrier family 3 member 1
714035
Mouse
MGI:1195264
20532
Rat
RGD:3709
29484
Dog
solute carrier family 3 member 1
VGNC:46409
403700
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 3 member 1
Macaque
solute carrier family 3 member 1
Mouse
Rat
Dog
solute carrier family 3 member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q07837-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Defective SLC3A1 causes cystinuria (CSNU)
Reactome
Defective SLC7A9 causes cystinuria (CSNU)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Defective SLC3A1 causes cystinuria (CSNU)
Defective SLC7A9 causes cystinuria (CSNU)
Disease
Disorders of transmembrane transporters
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (75)
1 – 10 of 75
SLC7A9
Tbio
Family:  Transporter
Novelty:  0.0096383
Score:  0.994
Data Source:  Reactome,STRINGDB
PREPL
Tchem
Family:  Enzyme
Novelty:  0.02310586
Score:  0.91
Data Source:  STRINGDB
CAMKMT
Tbio
Family:  Enzyme
Novelty:  0.00382649
Score:  0.902
Data Source:  STRINGDB
PPM1B
Tchem
Family:  Enzyme
Novelty:  0.02370446
Score:  0.891
Data Source:  STRINGDB
SLC7A8
Tbio
Family:  Transporter
Novelty:  0.03433454
Score:  0.802
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.784
Data Source:  STRINGDB
SLC7A7
Tbio
Family:  Transporter
Novelty:  0.01503788
Score:  0.773
Data Source:  STRINGDB
SLC7A6
Tbio
Family:  Transporter
Novelty:  0.02732334
Score:  0.759
Data Source:  STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
Score:  0.743
Data Source:  STRINGDB
SLC6A19
Tchem
Family:  Transporter
Novelty:  0.01581031
Score:  0.685
Data Source:  STRINGDB
Publication Statistics
PubMed Score  310.85

PubMed score by year
PubTator Score  135.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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