MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1
Protein Summary
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
- ENST00000307940
- ENSP00000309973
- ENSG00000143384
- ENST00000369026
- ENSP00000358022
- BCL2L3
- TM
- EAT
- MCL1L
- MCL1S
- Mcl-1
- BCL2L3
- MCL1-ES
- bcl2-L-3
- mcl1/EAT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 1 | ||
virus perturbation | 1 | ||
chemical | 0.99 | ||
PubMedID | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2236.32 (req: < 5)
Gene RIFs: 672 (req: <= 3)
Antibodies: 1239 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2236.32 (req: >= 5)
Gene RIFs: 672 (req: > 3)
Antibodies: 1239 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 671
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2