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Tchem
MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

Protein Summary
Description
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307940
  • ENSP00000309973
  • ENSG00000143384
  • ENST00000369026
  • ENSP00000358022

Symbol
  • BCL2L3
  • TM
  • EAT
  • MCL1L
  • MCL1S
  • Mcl-1
  • BCL2L3
  • MCL1-ES
  • bcl2-L-3
  • mcl1/EAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
virus perturbation
1
chemical
0.99
PubMedID
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2236.32   (req: < 5)
Gene RIFs: 533   (req: <= 3)
Antibodies: 1239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2236.32   (req: >= 5)
Gene RIFs: 533   (req: > 3)
Antibodies: 1239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 671
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2