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Tchem
MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

Protein Summary
Description
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307940
  • ENSP00000309973
  • ENSG00000143384
  • ENST00000369026
  • ENSP00000358022

Symbol
  • BCL2L3
  • TM
  • EAT
  • MCL1L
  • MCL1S
  • Mcl-1
  • BCL2L3
  • MCL1-ES
  • bcl2-L-3
  • mcl1/EAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
virus perturbation
1
chemical
0.99
PubMedID
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2395.8   (req: < 5)
Gene RIFs: 533   (req: <= 3)
Antibodies: 1239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2395.8   (req: >= 5)
Gene RIFs: 533   (req: > 3)
Antibodies: 1239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 592
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (278)
BCL2L11
Tchem
Novelty:  0.00055914
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
BAK1
Tbio
Novelty:  0.00381053
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.965
Data Source:  BioPlex,STRINGDB
Q9BXH1
Tbio
Novelty:  0.00773944
p_int:  0.999999848
p_ni:  9e-8
p_wrong:  6.2e-8
Score:  0.984
Data Source:  BioPlex,STRINGDB
BAX
Tchem
Novelty:  0.00150653
p_int:  0.999471446
p_ni:  0.000528554
Score:  0.996
Data Source:  BioPlex,STRINGDB
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.998781932
p_ni:  0.001218067
p_wrong:  1e-9
Data Source:  BioPlex
PRKAA1
Tclin
Family:  Kinase
Novelty:  0.01205826
p_int:  0.997178536
p_ni:  0.002821464
Score:  0.613
Data Source:  BioPlex,STRINGDB
ZAR1L
Tdark
Novelty:  0.08793345
p_int:  0.985690761
p_ni:  0.014288461
p_wrong:  0.000020778
Data Source:  BioPlex
EDNRA
Tclin
Family:  GPCR
Novelty:  0.00045591
p_int:  0.980366422
p_ni:  0.019633577
p_wrong:  1e-9
Score:  0.561
Data Source:  BioPlex,STRINGDB
SERPINB7
Tbio
Novelty:  0.01685387
p_int:  0.978580723
p_ni:  0.012452949
p_wrong:  0.008966328
Data Source:  BioPlex
STARD9
Tbio
Novelty:  0.2061653
p_int:  0.977501475
p_ni:  0.022498138
p_wrong:  3.87e-7
Score:  0.261
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
4
4
97.2
eosinophil count
3
3
5
96.8
granulocyte percentage of myeloid white cells
1
2
2
93
eosinophil percentage of leukocytes
2
2
3
91.8
vital capacity
2
2
2
90.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
4
97.2
eosinophil count
5
96.8
granulocyte percentage of myeloid white cells
2
93
eosinophil percentage of leukocytes
3
91.8
vital capacity
2
90.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MCL1, BCL2 family apoptosis regulator
VGNC:1312
457274
Macaque
MCL1, BCL2 family apoptosis regulator
707539
Mouse
MGI:101769
17210
Dog
MCL1, BCL2 family apoptosis regulator
VGNC:43079
403537
Horse
MCL1, BCL2 family apoptosis regulator
VGNC:20032
100054765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MCL1, BCL2 family apoptosis regulator
Macaque
MCL1, BCL2 family apoptosis regulator
Mouse
Dog
MCL1, BCL2 family apoptosis regulator
Horse
MCL1, BCL2 family apoptosis regulator
Publication Statistics
PubMed Score 2395.80
PubMed score by year
PubTator Score 1395.03
PubTator score by year
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Related Publications
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PMID
Year
Title