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Tchem
MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

Protein Classes
Protein Summary
Description
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307940
  • ENSP00000309973
  • ENSG00000143384
  • ENST00000369026
  • ENSP00000358022

Symbol
  • BCL2L3
  • TM
  • EAT
  • MCL1L
  • MCL1S
  • Mcl-1
  • BCL2L3
  • MCL1-ES
  • bcl2-L-3
  • mcl1/EAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
virus perturbation
1
chemical
0.99
PubMedID
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2302.1   (req: < 5)
Gene RIFs: 533   (req: <= 3)
Antibodies: 1239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2302.1   (req: >= 5)
Gene RIFs: 533   (req: > 3)
Antibodies: 1239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 320
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
1
1
69
forced expiratory volume
1
1
1
60.8
sum of eosinophil and basophil counts
1
1
1
25.7
eosinophil count
1
1
1
22
pulse pressure measurement
1
1
1
9.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
69
forced expiratory volume
1
60.8
sum of eosinophil and basophil counts
1
25.7
eosinophil count
1
22
pulse pressure measurement
1
9.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MCL1, BCL2 family apoptosis regulator
VGNC:1312
457274
Macaque
MCL1, BCL2 family apoptosis regulator
707539
Mouse
MGI:101769
17210
Dog
MCL1, BCL2 family apoptosis regulator
VGNC:43079
403537
Horse
MCL1, BCL2 family apoptosis regulator
VGNC:20032
100054765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MCL1, BCL2 family apoptosis regulator
Macaque
MCL1, BCL2 family apoptosis regulator
Mouse
Dog
MCL1, BCL2 family apoptosis regulator
Horse
MCL1, BCL2 family apoptosis regulator
Protein Structure (54 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q07820-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 54
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Protein-Protein Interactions (278)
1 – 10 of 278
BCL2L11
Tbio
Novelty: 0.00055914
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
BAK1
Tbio
Novelty: 0.00381053
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
BBC3
Tbio
Novelty: 0.00773944
p_int: 0.999999848
p_ni: 9e-8
p_wrong: 6.2e-8
Score: 0.984
Data Source: BioPlex,STRINGDB
BAX
Tchem
Novelty: 0.00150653
p_int: 0.999471446
p_ni: 0.000528554
Score: 0.996
Data Source: BioPlex,STRINGDB
TRIM11
Tbio
Family: Enzyme
Novelty: 0.02243955
p_int: 0.998781932
p_ni: 0.001218067
p_wrong: 1e-9
Data Source: BioPlex
PRKAA1
Tclin
Family: Kinase
Novelty: 0.01205826
p_int: 0.997178536
p_ni: 0.002821464
Score: 0.613
Data Source: BioPlex,STRINGDB
ZAR1L
Tdark
Novelty: 0.08793345
p_int: 0.985690761
p_ni: 0.014288461
p_wrong: 0.000020778
Data Source: BioPlex
EDNRA
Tclin
Family: GPCR
Novelty: 0.00045591
p_int: 0.980366422
p_ni: 0.019633577
p_wrong: 1e-9
Score: 0.561
Data Source: BioPlex,STRINGDB
SERPINB7
Tbio
Novelty: 0.01685387
p_int: 0.978580723
p_ni: 0.012452949
p_wrong: 0.008966328
Data Source: BioPlex
STARD9
Tbio
Novelty: 0.2061653
p_int: 0.977501475
p_ni: 0.022498138
p_wrong: 3.87e-7
Score: 0.261
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2302.10

PubMed score by year
PubTator Score  1395.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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