Tchem BAX Apoptosis regulator BAX

Protein Summary

Description

Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q07812
• A8K4W1
• P55269
• Q07814
• Q07815
• Q8WZ49
• Q9NR76
• Q9NYG7
• Q9UCZ6
• Q9UCZ7
• Q9UQD6

Gene Name

• BAX

Ensembl ID

• ENST00000293288
• ENSP00000293288
• ENSG00000087088
• ENST00000345358
• ENSP00000263262
• ENST00000354470
• ENSP00000346461
• ENST00000356483
• ENSP00000348871
• ENST00000415969
• ENSP00000389971
• ENST00000515540
• ENSP00000426328

Symbol

• BCL2L4
• BCL2L4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
disease perturbation	0.99
cellular component	0.92
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Apoptosis Regulator Bax

DTO Classes

Protein / Signaling / Apoptosis Regulator Bax

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.51   (req: < 5)

Gene RIFs: 746   (req: <= 3)

Antibodies: 1862   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.51   (req: >= 5)

Gene RIFs: 746   (req: > 3)

Antibodies: 1862   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 96

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0