Protein Summary
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in ...more
- ENST00000293288
- ENSP00000293288
- ENSG00000087088
- ENST00000345358
- ENSP00000263262
- ENST00000354470
- ENSP00000346461
- ENST00000356483
- ENSP00000348871
- ENST00000415969
- ENSP00000389971
- ENST00000515540
- ENSP00000426328
- BCL2L4
- BCL2L4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
disease perturbation | 0.99 | ||
cellular component | 0.92 | ||
transcription factor binding site profile | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 424.61 (req: < 5)
Gene RIFs: 746 (req: <= 3)
Antibodies: 1862 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 424.61 (req: >= 5)
Gene RIFs: 746 (req: > 3)
Antibodies: 1862 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 96
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (131)
BCL2L2
Novelty: 0.00430896
p_int: 0.999995545
p_ni: 0.000004455
Score: 0.749
Data Source: BioPlex,STRINGDB
BCL2
Novelty: 0.00608635
p_int: 0.999881038
p_ni: 0.000118962
Score: 0.967
Data Source: BioPlex,STRINGDB
MCL1
Novelty: 0.00046181
p_int: 0.999471446
p_ni: 0.000528554
Score: 0.996
Data Source: BioPlex,STRINGDB
BCL2L15
Novelty: 0.11260258
p_int: 0.999350647
p_ni: 0.000649353
Score: 0.365
Data Source: BioPlex,STRINGDB
BCL2L10
Novelty: 0.01389535
p_int: 0.997268349
p_ni: 0.002731651
Score: 0.473
Data Source: BioPlex,STRINGDB
BCL2L1
Novelty: 0.00018414
p_int: 0.996556649
p_ni: 0.003443351
Score: 0.998
Data Source: BioPlex,STRINGDB
BCL2L12
Novelty: 0.01773637
p_int: 0.995879491
p_ni: 0.004120509
Score: 0.579
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (2)
Downstream (1)
1 – 2 of 2
Pathways (117)
Reactome (20)
KEGG (44)
PathwayCommons (18)
WikiPathways (35)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation, translocation and oligomerization of BAX | ||||
Reactome | Apoptosis | ||||
Reactome | Apoptotic factor-mediated response | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation, translocation and oligomerization of BAX | ||||
Apoptosis | ||||
Apoptotic factor-mediated response | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (110)
Functions (8)
Components (14)
Processes (88)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | HGNC | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 5 | 6 | 96.1 | |||||
red blood cell distribution width | 4 | 3 | 5 | 95.1 | |||||
reticulocyte count | 6 | 4 | 12 | 94.4 | |||||
testosterone measurement | 6 | 6 | 6 | 88 | |||||
eosinophil count | 3 | 1 | 3 | 70.9 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte measurement | 6 | 96.1 | |||||
red blood cell distribution width | 5 | 95.1 | |||||
reticulocyte count | 12 | 94.4 | |||||
testosterone measurement | 6 | 88 | |||||
eosinophil count | 3 | 70.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | BCL2 associated X, apoptosis regulator | VGNC:10275 | 747093 | |||||
Macaque | BCL2 associated X, apoptosis regulator | 718948 | ||||||
Mouse | MGI:99702 | 12028 | ||||||
Rat | RGD:2192 | 24887 | ||||||
Dog | BCL2 associated X, apoptosis regulator | VGNC:38388 | 403523 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | BCL2 associated X, apoptosis regulator | |||||
Macaque | BCL2 associated X, apoptosis regulator | |||||
Mouse | ||||||
Rat | ||||||
Dog | BCL2 associated X, apoptosis regulator | |||||
Publication Statistics
PubMed Score 424.61
PubMed score by year
PubTator Score 6579.14
PubTator score by year
Related Publications
Text Mined References (885)
GeneRif Annotations (746)
Items per page:
0 of 0
PMID | Year | Title |
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