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Tbio
DLX2
Homeobox protein DLX-2

Protein Summary
Description
Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234198
  • ENSP00000234198
  • ENSG00000115844
  • ENST00000466293
  • ENSP00000446904

Symbol
  • TES1
  • TES-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
protein domain
0.85
PubMedID
0.85
virus perturbation
0.83
biological process
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.96   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.96   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
57.8
mathematical ability
1
1
1
46.9
body height
1
1
1
46.5
body fat percentage
1
1
1
33.1
refractive error measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
57.8
mathematical ability
1
46.9
body height
1
46.5
body fat percentage
1
33.1
refractive error measurement
1
24.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 2
VGNC:10768
459741
Mouse
MGI:94902
13392
Rat
RGD:1304853
296499
Dog
distal-less homeobox 2
VGNC:39990
100856541
Horse
distal-less homeobox 2
VGNC:51451
100063859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 2
Mouse
Rat
Dog
distal-less homeobox 2
Horse
distal-less homeobox 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q07687-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Preimplantation Embryo
Name
Explore in Pharos
Explore in Source
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Preimplantation Embryo
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (116)
1 – 10 of 116
IRX1
Tbio
Family:  TF
Novelty:  0.01754936
Score:  0.789
Data Source:  STRINGDB
ASCL1
Tbio
Family:  TF
Novelty:  0.00274239
Score:  0.758
Data Source:  STRINGDB
LHX6
Tbio
Family:  TF
Novelty:  0.01603143
Score:  0.734
Data Source:  STRINGDB
LMCD1
Tbio
Novelty:  0.06810419
Score:  0.712
Data Source:  STRINGDB
NEUROG2
Tbio
Family:  TF
Novelty:  0.00489481
Score:  0.689
Data Source:  STRINGDB
TBR1
Tbio
Family:  TF
Novelty:  0.00676736
Score:  0.687
Data Source:  STRINGDB
GAD1
Tbio
Family:  Enzyme
Novelty:  0.00067443
Score:  0.682
Data Source:  STRINGDB
OLIG2
Tbio
Family:  TF
Novelty:  0.0015221
Score:  0.673
Data Source:  STRINGDB
SOX9
Tbio
Family:  TF
Novelty:  0.00047439
Score:  0.663
Data Source:  STRINGDB
MEIS2
Tbio
Family:  TF
Novelty:  0.01393828
Score:  0.652
Data Source:  STRINGDB
Publication Statistics
PubMed Score  158.96

PubMed score by year
PubTator Score  57.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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