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Tbio
KHDRBS1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

Protein Summary
Description
Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5' ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327300
  • ENSP00000313829
  • ENSG00000121774
  • ENST00000492989
  • ENSP00000417731

Symbol
  • SAM68
  • p62
  • p68
  • Sam68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
hub protein
1
interacting protein
1
disease perturbation
0.99
virus perturbation
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.12   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.12   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (285)
1 – 10 of 285
KHDRBS2
Tbio
Novelty:  0.01986638
p_int:  0.999935182
p_ni:  0.000064818
Score:  0.44
Data Source:  BioPlex,STRINGDB
RARRES1
Tbio
Family:  Enzyme
Novelty:  0.04701793
p_int:  0.991562485
p_ni:  0.008437515
Data Source:  BioPlex
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.993
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.989
Data Source:  STRINGDB
PTK6
Tchem
Family:  Kinase
Novelty:  0.00480214
Score:  0.988
Data Source:  Reactome,STRINGDB
HNRNPC
Tbio
Novelty:  0.00136097
Score:  0.981
Data Source:  STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
Score:  0.971
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.97
Data Source:  STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
Score:  0.969
Data Source:  STRINGDB
RASA1
Tbio
Family:  Enzyme
Novelty:  0.00425286
Score:  0.961
Data Source:  STRINGDB
Pathways (207)
PTK6 Regulates Proteins Involved in RNA Processing (R-HSA-8849468)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
PTK6 Regulates Proteins Involved in RNA Processing
Reactome
Signal Transduction
Reactome
Signaling by Non-Receptor Tyrosine Kinases
Reactome
Signaling by PTK6
Name
Explore in Pharos
Explore in Source
PTK6 Regulates Proteins Involved in RNA Processing
Signal Transduction
Signaling by Non-Receptor Tyrosine Kinases
Signaling by PTK6
Gene Ontology Terms (28)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
1
1
0
3.8
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
0
3.8
17.8
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KH RNA binding domain containing, signal transduction associated 1
VGNC:8349
456705
Macaque
KH RNA binding domain containing, signal transduction associated 1
706598
Mouse
MGI:893579
20218
Rat
RGD:621459
117268
Dog
KH RNA binding domain containing, signal transduction associated 1
VGNC:42335
487316
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KH RNA binding domain containing, signal transduction associated 1
Macaque
KH RNA binding domain containing, signal transduction associated 1
Mouse
Rat
Dog
KH RNA binding domain containing, signal transduction associated 1
Publication Statistics
PubMed Score 206.12
PubMed score by year
PubTator Score 220.20
PubTator score by year